首页|Phenylpropanoids and triterpenoids from Tripterygium regelii and their anti-inflammatory activities
Phenylpropanoids and triterpenoids from Tripterygium regelii and their anti-inflammatory activities
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeTwo new compounds named cleroserroside C (1), schisphenlignan O (2), as well as twenty-one known compounds (3–23) were isolated from the roots of Tripterygium regelii. The structures of the new compounds were determined by 1D and 2D NMR spectra and HR-ESI-MS data. The known compounds were determined by comparing the 1D NMR data in the literature. All compounds were evaluated for anti-inflammatory activity using the LPS-induced RAW264.7 inflammatory cell model, and the results showed that compounds 1, 8-11, 15-16, and 20-21 had good anti-inflammatory activity (IC50 < 20 μM). The cytotoxicity of all compounds was tested by CCK-8 assay, using RAW264.7 cells. The results showed that all compounds had no cytotoxicity to RAW264.7 in the range of 0 ~ 200 μM.
NSTL
Elsevier
