Canavanine versus arginine: Prospects for cell-penetrating peptides
Calabretta, Lindsey O. 1Thomas, Vienna M. 2Raines, Ronald T.1
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作者信息
1. MIT
2. Wellesley Coll
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Abstract
Octanol-water partitioning experiments in the presence of carboxylate-, phosphate-, and sulfate -containing anionic lipids revealed that Ac-Cav-NH2 (where Cav refers to delta-oxa-arginine) partitions less into octanol than does Ac-Arg-NH2, suggesting that a cell-penetrating peptide based on canavanine would be relatively ineffective. (C) 2022 Published by Elsevier Ltd.
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Elsevier