首页|A new method for the evaluation of measurement uncertainty in strict accordance with measurement model: Determination of total thyroxine in human serum by triple isotope dilution mass spectrometry
A new method for the evaluation of measurement uncertainty in strict accordance with measurement model: Determination of total thyroxine in human serum by triple isotope dilution mass spectrometry
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NSTL
Elsevier
? 2022 Elsevier B.V.The rigorous and reasonable evaluation of uncertainty is crucial for the reliability of the results of a reference measurement procedure. A new uncertainty budget is proposed for uncertainty evaluation of a reference measurement procedure for total thyroxine in human serum based on isotope dilution liquid chromatography-mass spectrometry. In this work, a measurement model for uncertainty evaluation of triple isotope dilution-mass spectrometry was established. The propagation of uncertainties assigned to various input quantities was expressed in strict accordance with the measurement model. A detailed description of the uncertainty evaluation process for the measurement result of a specific serum is given, including the estimate of the input quantities and the determination of the combined standard uncertainty. The expanded uncertainty of the specific human serum (at coverage probability of 95%) was 4.8 nmol/L at the concentration level of 113.6 nmol/L.
NSTL
Elsevier
