首页|DIFFERENCES IN MULTI-MODAL ULTRASOUND IMAGING BETWEEN TRIPLE NEGATIVE AND NON-TRIPLE NEGATIVE BREAST CANCER
DIFFERENCES IN MULTI-MODAL ULTRASOUND IMAGING BETWEEN TRIPLE NEGATIVE AND NON-TRIPLE NEGATIVE BREAST CANCER
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NSTL
Elsevier
The objective of this study was to identify multi-modal ultrasound imaging parameters that could potentially help to differentiate between triple negative breast cancer (TNBC) and non-TNBC. Conventional ultrasonography, ultrasound strain elastography and 3-D ultrasound (3-D-US) findings from 50 TNBC and 179 non-TNBC patients were retrospectively reviewed. Immunohistochemical examination was used as the reference gold standard for cancer subtyping. Different ultrasound modalities were initially analyzed to define TNBC-related features. Subsequently, logistic regression analysis was applied to TNBC-related features to establish models for predicting TNBC. TNBCs often presented as micro-lobulated, markedly hypo-echoic masses with an abrupt interface (p = 0.015, 0.0015 and 0.004, compared with non-TNBCs, respectively) on conventional ultrasound, and showed a diminished retraction pattern phenomenon in the coronal plane (p = 0.035) on 3-D-US. Our findings suggest that B-mode ultrasound and 3-D-US in multi-modality ultrasonography could be a useful non-invasive technique for differentiating TNBCs from non-TNBCs. (E-mail: jwtian2004@163.com) (C) 2016 World Federation for Ultrasound in Medicine & Biology.
Triple negative breast cancerB-mode ultrasoundStrain elastographyThree-dimensional ultrasoundRetraction pattern
NSTL
Elsevier
