首页|Iron Single-Atom nanocatalysts in response to tumor microenvironment for highly efficient Chemo-chemodynamic therapy
Iron Single-Atom nanocatalysts in response to tumor microenvironment for highly efficient Chemo-chemodynamic therapy
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NSTL
Elsevier
Chemodynamic therapy (CDT) based on multifunctional nanoparticles (NPs) has occurred as an attractive cancer treatment that covers the shortage of nonnegligible limitations from single therapy. Herein, we synthesize a safe and universal CDT nanoparticle-iron single-atom nanoparticle (Fe SANP), in which Fe single-atom as the active catalytic site is anchored in a carbon framework with encapsulated doxorubicin (DOX). Fe SANPs work as catalase-like nanozyme for hydroxyl radicals (center dot OH) production. The prepared NPs (denoted as DOX@Fe SANPs) can efficiently mediate peroxidase-like activity with the existence of H(2)Othat enhances cancer cell elimination by generating abundant center dot OH. DOX@Fe SANPs exhibit a pH induced degradable character that contributes to specific drug release in the tumor microenvironment (TME). DOX@Fe SANPs produce ignorable systematic toxicity after biodegradation and drug delivery processes. Collectively, this study highlights the efficient anti-tumor performances of the iron single-atom nanocatalysts containing an anti-cancer drug DOX. (C) 2022 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
NSTL
Elsevier
