Tetrahedron letters2022，Vol.884.DOI:10.1016/j.tetlet.2021.153591

Regiodivergent synthesis of vinyl trifluoromethansulfonates gamma/delta lactones: Via 1,6 addition/intramolecular one-pot annulation of 1, 4-dihidropyridines derivated from pyridinyl propenones

Carmona-Reyes, Genaro Ballinas-Indili, Ricardo Elena Sanchez-Vergara, Maria Alfredo Toscano, R. Alvarez-Toledano, Cecilio
Tetrahedron letters2022，Vol.884.DOI:10.1016/j.tetlet.2021.153591
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  • NSTL
  • Elsevier

Regiodivergent synthesis of vinyl trifluoromethansulfonates gamma/delta lactones: Via 1,6 addition/intramolecular one-pot annulation of 1, 4-dihidropyridines derivated from pyridinyl propenones

Carmona-Reyes, Genaro 1Ballinas-Indili, Ricardo 1Elena Sanchez-Vergara, Maria 2Alfredo Toscano, R. 1Alvarez-Toledano, Cecilio1
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作者信息

  • 1. Univ Nacl Autonoma Mexico
  • 2. Univ Anahuac Mexico
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Abstract

We report a novel intramolecular 1,6 oxa-Michael addition on substituted dihydropyridines to obtain 5 and 6 member ring lactones in an one-pot reaction starting from activated pyridinyl propenones, without organic catalysis or presence of bulky groups in the Michael acceptor. A marked dependence on the regioselectivity of ring closure was found, dependent on the propenone used. (C) 2021 Elsevier Ltd. All rights reserved.

Key words

1/6 oxa-Michael addition/Activated pyridines/Pyridinyl propenones/Lactones/Ketene acetal/MICHAEL ADDITION/LACTONIZATION/CHEMISTRY

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
参考文献量22
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