首页|GSK669, a NOD2 receptor antagonist, inhibits thrombosis and oxidative stress via targeting platelet GPVI

GSK669, a NOD2 receptor antagonist, inhibits thrombosis and oxidative stress via targeting platelet GPVI

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原文链接
  • NSTL
  • Elsevier
Background and Purpose: Previously, we discovered that the activation of nucleotide-binding oligomerization domain 2 (NOD2) enhances platelet activation. We here investigated the antiplatelet and antithrombotic potential of GSK669, a NOD2 antagonist.

GSK669GPVINOD2AntithromboticAntioxidativeAnti-inflammatory

Pan, Guanxing、Chang, Lin、Zhang, Jianjun、Liu, Yangyang、Hu, Liang、Zhang, Si、Zhang, Jian、Qiao, Jianlin、Jakopin, Ziga、Hu, Hu、Dong, Jianzeng、Ding, Zhongren

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Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Shanghai 200032, Peoples R China

Zhengzhou Univ, Dept Cardiol, Affiliated Hosp 1, Zhengzhou 450018, Peoples R China

Shanghai Jiao Tong Univ, Sch Med, Dept Pathophysiol, Shanghai 200025, Peoples R China

Xuzhou Med Univ, Blood Dis Inst, Dept Hematol, Xuzhou 221004, Jiangsu, Peoples R China

Univ Ljubljana, Fac Pharm, Askerceva 7, SI-1000 Ljubljana, Slovenia

Zhejiang Univ, Dept Pathophysiol, Sch Med, Hangzhou 310012, Peoples R China

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2021

10.1016/j.bcp.2020.114315

Biochemical Pharmacology

Biochemical Pharmacology

ISTP
ISSN：0006-2952
年,卷(期)：2021.183
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