Surface & Coatings Technology2022，Vol.4338.DOI:10.1016/j.surfcoat.2022.128088

RGD-functionalization of anodized zirconium as a potential strategy for biomedical application: An in vitro study

de la Hoz, Maria Florencia Tano Sanchez, Andrea Gomez Mariscotti, Valentina Procaccini, Raul Micheletti, Melisa Barbini, Luciana Katunar, Maria R. Cere, Silvia
Surface & Coatings Technology2022，Vol.4338.DOI:10.1016/j.surfcoat.2022.128088
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  • NSTL
  • Elsevier

RGD-functionalization of anodized zirconium as a potential strategy for biomedical application: An in vitro study

de la Hoz, Maria Florencia Tano 1Sanchez, Andrea Gomez 2Mariscotti, Valentina 1Procaccini, Raul 1Micheletti, Melisa 3Barbini, Luciana 3Katunar, Maria R. 1Cere, Silvia1
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作者信息

  • 1. INTEMA UNMdP CONICET
  • 2. IMITAB UNVM CONICET
  • 3. Univ Nacl Mar del Plata
  • 折叠

Abstract

The effect of functionalization of anodized zirconium (Zr) with RGD peptides on cell behavior as a feasible approach to stimulate early bone integration is presented. The surface modifications were evaluated by Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). Electrochemical tests were performed to determine the effect of functionalization on the stability of the anodized zirconium oxide film. Finally, the biocompatibility of the material was evaluated in an in vitro cell model. Surface analysis showed the presence of peptides on the surface after functionalization, and that the crystal structure of the oxide formed by anodization is predominantly monoclinic. The immobilization of RGD peptides on anodized Zr does not alter the corrosion protection provided by the anodic oxide and significantly promote cell adhesion and spreading in vitro. Thus, the combination of RGD peptides with anodic oxide on Zr surface would represent a useful strategy to increases the biocompatibility of the material.

Key words

RGD peptide/Zirconium/Anodization/Surface characterization/In vitro assay/Biomimetic surface/SURFACE MODIFICATION/TITANIUM SURFACES/OXIDE-FILMS/IMPEDANCE SPECTROSCOPY/CORROSION-RESISTANCE/RAMAN-SPECTROSCOPY/OXIDIZED TITANIUM/ADHESIVE PEPTIDES/CELL-ADHESION/XPS

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出版年

2022
Surface & Coatings Technology

Surface & Coatings Technology

ISTP
ISSN：0257-8972
参考文献量77
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