Abstract
The synthetically useful aldehyde 2E,4E-5-bromo-2,4-pentadienal was subjected to the enantioselective Trost alkynylation protocol, yielding highly functionalized propargylic secondary alcohols in an enantioselective manner. In most cases, the isolated yields and enantiomeric excess of the products were modest to high, but several products were formed in both high yields and enantiomeric excess. (C) 2022 The Author(s). Published by Elsevier Ltd.
NSTL
Elsevier