首页|Colorectal cancer: Greater neo-angiogenesis, less perforation, worst oncological outcomes
Colorectal cancer: Greater neo-angiogenesis, less perforation, worst oncological outcomes
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NSTL
Elsevier
Little attention has been paid to the anatomopathological factors and pathophysiologic mechanisms involved in CRC perforation。 Perforation is one of the most serious complications occurring up to 11% of the cases and may also be the first manifestation of the tumor。 Differentiation and angiogenesis have an important role in the tumor perforation mechanism。 On the one hand， a greater expression of vascularization optimizes the supply of oxygen to the tumor and thus entails a lower necrotic wall rate and thus of perforation， on the other it is associated with a lower rate of differentiation and hence to a more aggressive cancer cells。
NSTL
Elsevier
