Medical hypotheses2021，Vol.1483.DOI:10.1016/j.mehy.2021.110508

Antihistamine and cationic amphiphilic drugs, old molecules as new tools against the COVID-19?

Falcao Faria, Clara Gitahy Weiner, Luisa Petrignet, Julien Hingray, Coraline De Pellon Santamaria, Angel Ruiz Villoutreix, Bruno O. Beaune, Philippe Leboyer, Marion Javelot, Herve
Medical hypotheses2021，Vol.1483.DOI:10.1016/j.mehy.2021.110508
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  • NSTL
  • Elsevier

Antihistamine and cationic amphiphilic drugs, old molecules as new tools against the COVID-19?

Falcao Faria, Clara Gitahy 1Weiner, Luisa 2Petrignet, Julien 3Hingray, Coraline 4De Pellon Santamaria, Angel Ruiz 5Villoutreix, Bruno O. 6Beaune, Philippe 7Leboyer, Marion 8Javelot, Herve9
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作者信息

  • 1. Fed Univ Rio de Janeiro UFRJ, Inst Psychiat, Rio De Janeiro, Brazil
  • 2. CHU Strasbourg, Clin Psychiat, Strasbourg, France
  • 3. Univ Tours, Fac Sci & Tech, Lab Synth & Isolement Mol BioAct, SIMBA,EA 7502, Tours, France
  • 4. Pole Hosp Univ Psychiat Adultes Grand Nancy, Ctr Psychotherap Nancy, Laxou, France
  • 5. Donostia Univ Hosp, Dept Psychiat, Donostia San Sebastian, Guipuzcoa, Spain
  • 6. Univ Paris, Hop Robert Debre, Inserm U1141, NeuroDiderot, F-75019 Paris, France
  • 7. Univ Paris, INSERM, U1138, Ctr Rech Cordeliers, F-75006 Paris, France
  • 8. Univ Paris Est Creteil UPEC, Dept Med Univ Psychiat & Addictol DMU ADAPT, IMRB,Hop Henri Mondor,AP
  • 9. Etab Publ Sante Alsace Nord, Brumath, France
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Abstract

Several studies have reported that certain psychoactive drugs could have a protective effect against SARS-CoV-2. Herein, we propose that antihistamines (anti-H1) and cationic amphiphilic drugs (CAD), specifically, have the capacity to disrupt virus entry and replication. In addition, several of these molecules have limited side effects and as such could be promising prophylactic candidates against SARS-CoV-2 infection.

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出版年

2021
Medical hypotheses

Medical hypotheses

SCI
ISSN：0306-9877
被引量2
参考文献量26
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