首页|Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men.

Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy men.

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  • NSTL
  • Elsevier
We investigated peripheral blood mononuclear cell gene expression responses to acute psychosocial stress to identify molecular pathways relevant to the stress response. Blood samples were obtained from 10 healthy male subjects before, during and after (at 0, 30, and 60 min) a standardized psychosocial laboratory stressor. Ribonucleic acid (RNA) was extracted and gene expression measured by hybridization to a 20,000-gene microarray. Gene Set Expression Comparisons (GSEC) using defined pathways were used for the analysis. Forty-nine pathways were significantly changed from baseline to immediately after the stressor (p<0.05), implicating cell cycle, cell signaling, adhesion and immune responses. The comparison between stress and recovery (measured 30 min later) identified 36 pathways, several involving stress-responsive signaling cascades and cellular defense mechanisms. These results have relevance for understanding molecular mechanisms of the physiological stress response, and might be used to further study adverse health outcomes of psychosocial stress.

Adrenocorticotropic HormoneAdultGene ExpressionGene Expression ProfilingHumansHydrocortisoneInterleukin-6LeukocytesMononuclearMaleMiddle AgedNorethandroloneOligonucleotide Array Sequence AnalysisPsychometricsSignal TransductionStressPsychologicalTime FactorsTranscription FactorsYoung Adult*成年人基因表达氢化可的松白细胞介素6白细胞单核诺乙龙寡核苷酸序列分析心理测定学信号传递应激心理学时间因素转录因子

Nater UM、Whistler T、Lonergan W

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Chronic Viral Diseases Branch, National Center for Zoonotic, Vector-borne and Enteric Diseases, Centers for Disease Control & Prevention, 1600 Clifton Rd, MS-G41, Atlanta, GA 30329, USA.

2009

10.1016/j.biopsycho.2009.06.009

Biological Psychology

Biological Psychology

ISSHP
ISSN：0301-0511
年,卷(期)：2009.82(2)
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