首页|Derrisrobustones A-D, isoflavones from the twig extract of Derris robusta (DC.) Benth. and their alpha-glucosidase inhibitory activity
Derrisrobustones A-D, isoflavones from the twig extract of Derris robusta (DC.) Benth. and their alpha-glucosidase inhibitory activity
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NSTL
Elsevier
Three previously undescribed isoflavones, derrisrobustones A-C, and a previously undescribed natural isoflavone, derrisrobustone D, along with eight known isoflavones, were isolated from the twig extract of Derris robusta (DC.) Benth. All structures were identified by extensive spectroscopic analysis. Derrisrobustones A-C were obtained as scalemic mixtures and were resolved by chiral HPLC. The (1 & DPRIME;R, 2 & DPRIME;R) absolute configuration of (+)-derrisrobustone B was established by single-crystal X-ray crystallography using Cu K alpha radiation. The absolute configurations of derrisrobustones A and C were determined by analysis of experimental and calculated ECD data. All compounds were evaluated for their alpha-glucosidase inhibitory activity. Of these, derrubone displayed the best alpha-glucosidase inhibitory activity with an IC50 value of 64.2 mu M.
NSTL
Elsevier
