Phytochemistry2022，Vol.1987.DOI:10.1016/j.phytochem.2022.113168

Derrisrobustones A-D, isoflavones from the twig extract of Derris robusta (DC.) Benth. and their alpha-glucosidase inhibitory activity

Suthiphasilp, Virayu Payaka, Apirak Chaiyosang, Boonyanoot Harding, David J. Phuphong, Worrapong Tontapha, Sarawut Laphookhieo, Surat Tantapakul, Cholpisut
Phytochemistry2022，Vol.1987.DOI:10.1016/j.phytochem.2022.113168
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  • NSTL
  • Elsevier

Derrisrobustones A-D, isoflavones from the twig extract of Derris robusta (DC.) Benth. and their alpha-glucosidase inhibitory activity

Suthiphasilp, Virayu 1Payaka, Apirak 2Chaiyosang, Boonyanoot 3Harding, David J. 2Phuphong, Worrapong 2Tontapha, Sarawut 2Laphookhieo, Surat 1Tantapakul, Cholpisut2
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作者信息

  • 1. Mae Fah Luang Univ
  • 2. Walailak Univ
  • 3. Khon Kaen Univ
  • 折叠

Abstract

Three previously undescribed isoflavones, derrisrobustones A-C, and a previously undescribed natural isoflavone, derrisrobustone D, along with eight known isoflavones, were isolated from the twig extract of Derris robusta (DC.) Benth. All structures were identified by extensive spectroscopic analysis. Derrisrobustones A-C were obtained as scalemic mixtures and were resolved by chiral HPLC. The (1 & DPRIME;R, 2 & DPRIME;R) absolute configuration of (+)-derrisrobustone B was established by single-crystal X-ray crystallography using Cu K alpha radiation. The absolute configurations of derrisrobustones A and C were determined by analysis of experimental and calculated ECD data. All compounds were evaluated for their alpha-glucosidase inhibitory activity. Of these, derrubone displayed the best alpha-glucosidase inhibitory activity with an IC50 value of 64.2 mu M.

Key words

Derris robusta/Leguminosae/Isoflavone/a-Glucosidase inhibitory activity/FLAVONOIDS/PRINCIPLES/FRUITS/STEMS/ROOT

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出版年

2022
Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
被引量1
参考文献量28
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