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Metal-free synthesis of 5-trifluoromethyltetrazoles

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  • NSTL
  • Elsevier
An efficient transition-metal-free method for the synthesis of 5-trifluoromethyltetrazoles from arenediazonium tetrafluoroborates is reported, which relies on the use of trifluoroacetaldehyde N-tosylhydra-zone as a convenient 2,2,2-trifluorodiazoethane source. The reaction proceeds in good to excellent yields and shows a high functional group tolerance.CO 2022 Elsevier Ltd. All rights reserved.

TrifluormethylationTetrazoleCycloadditionFluorineMetal-free222-TRIFLUORODIAZOETHANE CF3CHN2TRIFLUOROMETHYLATIONTRIFLUORODIAZOETHANECYCLOADDITION

Lin, Xi、Luo, Beibei、He, Wenqin、Lu, Qingkai、Li, Longjia、Zheng, Huirong、Wu, Wei、Weng, Zhiqiang

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Minjiang Univ

Fuzhou Univ

2022

10.1016/j.tetlet.2022.153717

Tetrahedron letters

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CCR
ISSN：0040-4039
年,卷(期)：2022.95
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