Fitoterapia2022，Vol.1588.DOI:10.1016/j.fitote.2022.105168

Small Molecule Accurate Recognition Technology accelerated isolation of structurally diverse sesquiterpenes from Litsea lancilimba Merr.

Zhang Y.-J. Bai M. Yan Q.-L. Huang X.-X. Li K.-X. Zheng J. Song S.-J.
Fitoterapia2022，Vol.1588.DOI:10.1016/j.fitote.2022.105168
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  • NSTL
  • Elsevier

Small Molecule Accurate Recognition Technology accelerated isolation of structurally diverse sesquiterpenes from Litsea lancilimba Merr.

Zhang Y.-J. 1Bai M. 1Yan Q.-L. 1Huang X.-X. 1Li K.-X. 2Zheng J. 2Song S.-J.1
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作者信息

  • 1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development Liaoning Province Engineering Research Center of Natural Medicine Active Molecule Research & Development Liaoning Province Key Laboratory of Natural Bioactive Co
  • 2. Wuya College of Innovation Shenyang Pharmaceutical University
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Abstract

? 2022Four undescribed sesquiterpenes (1–4) and 20 known sesquiterpenes (5–24) were obtained from the fruits of Litsea lancilimba Merr. by Small Molecule Accurate Recognition Technology (SMART). The gross structures and the relative configurations of the new compounds were deduced by spectroscopic data analysis. The absolute configurations were defined by comparison of their experimental and calculated electronic circular dichroism (ECD) spectra data. All compounds were screened for their neuroprotective effects against H2O2-induced SH-SY5Y cells injury. Compounds 2, 3, 7, 8 and 13 exhibited comparable neuroprotective activity to the positive trolox at 50 μM.

Key words

Lauraceae/Litsea lancilimba Merr./Neuroprotective activities/Sesquiterpenes/Small molecule accurate recognition technology

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量4
参考文献量43
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