Surface & Coatings Technology2022，Vol.4339.DOI:10.1016/j.surfcoat.2022.128159

Early osseointegration of strontium-doped coatings on titanium implants in an osteoporotic rat model

Rosa Katunar, Maria Ignacio Pastore, Juan Cisilino, Adrian Merlo, Julieta Salemme Alonso, Leandro Baca, Matias Haddad, Kahlil Cere, Silvia Ballarre, Josefina
Surface & Coatings Technology2022，Vol.4339.DOI:10.1016/j.surfcoat.2022.128159
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  • NSTL
  • Elsevier

Early osseointegration of strontium-doped coatings on titanium implants in an osteoporotic rat model

Rosa Katunar, Maria 1Ignacio Pastore, Juan 2Cisilino, Adrian 1Merlo, Julieta 1Salemme Alonso, Leandro 3Baca, Matias 4Haddad, Kahlil 4Cere, Silvia 1Ballarre, Josefina1
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作者信息

  • 1. Natl Univ Mar del Plata
  • 2. Natl Res Council CONICET
  • 3. Serena Biointegrables
  • 4. Oscar Alende Gen Hosp
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Abstract

Osteoporosis is a skeletal disorder characterized by a decrease in bone strength leading to a higher risk of fracture. In this scenario, many osteoporotic patients require permanent prosthesis. Surface modification is a strategy to improve the osseointegration for cementless implants. This work assesses the in vivo performance of a surface modification consisting in a bioactive silica-based layer with strontium-doped bioactive glass particles. The layer was made by sol-gel and applied onto titanium nail-shaped implants. Osseointegration tests were performed on an osteoporotic rat model generated by ovariectomization. The effectiveness of the osteoporotic rat model was systematically analyzed for structure and bone quality using classic and novel techniques: nano indentation, micro-Raman spectroscopy and digital image processing. It was found that Sr-glass coatings applied on nail-shaped implants result with lower numbers of particles than for plane samples. The positive effect of bioactive Sr-glass coatings on the new bone tissue formation was evident from the results of the Raman tests. Besides, histomorphometric results showed that the newly formed bone thicknesses around coated Sr-bioactive implants are 15% larger than those formed around titanium materials 15 and 30 days after implantation. These results indicated that even when the nail-shaped implants have a relative low number of bioactive Sr-glass particles, they have a positive effect to induce the formation of new bone. Further research is needed to find the means to increase the number of particles in the coating, while tests at longer times are necessary to investigate the period of effectiveness.

Key words

Osteoporotic rat model/Titanium implants/Strontium bioactive glasses/micro-Raman analysis/Osseointegration/SURFACE MODIFICATION/IN-VITRO/BIOACTIVE GLASSES/45S5 BIOGLASS(R)/ANODIC-OXIDATION/PHOSPHORIC-ACID/BONE/QUALITY/CHEMISTRY/OSTEOBLASTS

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出版年

2022
Surface & Coatings Technology

Surface & Coatings Technology

ISTP
ISSN：0257-8972
被引量2
参考文献量71
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