首页|Epinastine inhibits eosinophil chemotaxis and adhesion molecules in atopic dermatitis.
Epinastine inhibits eosinophil chemotaxis and adhesion molecules in atopic dermatitis.
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NSTL
PURPOSE: To investigate the effects of epinastine on eosinophil chemotaxis and changes in eosinophil adhesion molecules induced by epinastine and three other antiallergic agents, using eosinophils of atopic dermatitis (AD) patients. RESULTS: Epinastine reduced eosinophil chemotaxis toward eotaxin when the eosinophils had been prestimulated with interleukin (IL)-5, but given alone it did not alter eosinophil chemotaxis toward IL-5. CD11b expression was inhibited when peripheral blood was prestimulated with IL-5, but eosinophil adhesion molecule expression was not altered. CONCLUSIONS: Epinastine suppresses allergic inflammation not only through its strong antihistamine and antimediator effects, but also by inhibiting eosinophilic chemotaxis and the expression of adhesion molecules involved in chemotaxis, especially CD11b.
EosinophilsChemotaxisProcess of adhesionDermatitisAtopicepinastine嗜酸细胞趋化性皮炎特应性
Matsukura M、Yajima A、Yamazaki F、Yudate T、Yamada H、Tezuka T
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Department of Dermatology, Kinki University School of Medicine, Osaka, Japan.
NSTL
