首页|Pore architecture influences the enzyme immobilization performance of mesoporous silica nanospheres

Pore architecture influences the enzyme immobilization performance of mesoporous silica nanospheres

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Immobilized enzymes on silica nano-carriers are stable biocatalysts with the potential for use in a plethora of applications.Studying how the structural characteristics of silica nano-carriers influence the performance of immobilized enzymes allows for the optimization of performance.This work investigates the influence of the pore architecture of silica nanospheres on enzyme loading,release,and reusability.Compared to dendritic mesoporous silica nanospheres(DMSN)with funnel-shaped wide-open pores,fractal silica nanoparticles(FSN)have a far more complex pore structure.FSN showed significantly higher immobilization capacity,sustained release,and enhanced reusability towards two model enzymes.The knowledge gained from this work paves the way for the rational design of enzyme nano-carriers for various applications.

Enzyme immobilizationPore architectureFractal silica nanoparticlesDendritic mesoporous silica nanoparticlesNano-carriers

Sukitha Geethma Kothalawala、Jinqing Jiao、Robert Speight

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Australian Institute for Bioengineering and Nanotechnology,The University of Queensland,Brisbane,Queensland,4072,Australia

2022

10.1016/j.micromeso.2022.111963

Microporous and mesoporous materials

Microporous and mesoporous materials

EISCI
ISSN：1387-1811
年,卷(期)：2022.338
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