首页|Impact of Pre-Stroke Dementia or Mild Cognitive Impairment on Stroke Outcome: A Systematic Review and Meta-Analysis

Impact of Pre-Stroke Dementia or Mild Cognitive Impairment on Stroke Outcome: A Systematic Review and Meta-Analysis

扫码查看
原文链接
  • NSTL
  • Karger
Background and Objective: Pre-stroke dementia (PSD) and pre-stroke mild cognitive impairment (PSMCI) are important risk factors for stroke. The present meta-analysis aimed to investigate the impact of PSD or PSMCI on stroke outcomes. Methods: Electronic databases (PubMed, EMbase, Google Scholar, Cochrane Library, and TRIP) were screened for eligible studies published prior to March 31, 2021. Risk ratios (RR) and mean differences with 95% confidence intervals (CIs) using random or fixed effect models were used to calculate pooled estimates. Study quality was assessed using the Newcastle Ottawa Scale. Results: Fifteen studies were included in our meta-analysis. Pooled data from ten studies involving 3,107 PSD and 20,645 non-PSD subjects showed a higher risk of mortality in PSD patients (RR = 2.03; 95% CI: 1.40–2.91; I 2 = 89%). Risk of recurrent stroke risk was observed more in patients with PSD compared to non-PSD patients (RR = 2.02; 95% CI: 1.40–2.91; I 2 = 0%). Three studies involving 300 mild cognitive impairment (MCI) and 1,025 normal cognition subjects showed a significant increased risk of mortality in stroke patients with MCI (RR = 2.43; 95% CI: 1.81–3.27; I 2 = 20%). However, elevated stroke severity was not observed in PSMCI patients. Conclusions: Our meta-analysis shows an increased risk of mortality in stroke patients with a history of PSD and PSMCI. Proper clinical management and increased attention are therefore required for the prevention and management of stroke in patients with cognitive deficits.

Pre-strokeMild cognitive impairmentPre-stroke dementiaMeta-analysisStrokeCognitionSystematic reviews

Huanqing,Yu、Shufang,Ding、Wei,Wei、Feng,Guo、Zhongnan,Li、Quan,Yuan、Xin,Zhao

展开 >

Department of Geriatrics, Qingdao Fifth People’s Hospital, Qingdao, China

Department of Geriatrics, Qingdao Fuwai Cardiovascular Hospital, Qingdao, China

Department of Supply Room, Qingdao Fifth People’s Hospital, Qingdao, China

Department of Emergency, Qingdao Fifth People’s Hospital, Qingdao, China

Department of Preventive Medicine, Qingdao Fifth People’s Hospital, Qingdao, China

Department of First Stationed Outpatient, No. 971 PLA Hospital, Qingdao, China

展开 >

2022

10.1159/000522302

Dementia and geriatric cognitive disorders

Dementia and geriatric cognitive disorders

SCI
ISSN：1420-8008
年,卷(期)：2022.51(2)
  • 1
  • 35