A novel and unexpected one pot synthesis of pyrrolo[1,2-a]quinolines
Sansom, Geraud N. 1Semken, Jessica 1Kelso, Michael J. 1Richardson, Christopher1
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作者信息
1. Univ Wollongong
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Abstract
A new low temperature route to pyrrolo[1,2-a]quinolines bearing ester groups in the 5-position is reported. The reaction mechanism was found to depend on the reaction temperature. At low temperatures it is proposed the reaction proceeds though an addition-intramolecular SNAr-elimination pathway. This method should find wider use as it avoids high boiling point solvents and affords compatibility with thermosensitive substrates.(c) 2022 Elsevier Ltd. All rights reserved.
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Elsevier