首页|New disposable ion-selective sensors for the determination of dabigatran etexilate: The oral anticoagulant of choice in patients with non-valvular atrial fibrillation and COVID-19 infection
New disposable ion-selective sensors for the determination of dabigatran etexilate: The oral anticoagulant of choice in patients with non-valvular atrial fibrillation and COVID-19 infection
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NSTL
Elsevier
? 2022 Elsevier LtdSelective, sensitive, and reproducible ion-selective electrodes containing dabigatran etexilate- phosphotungstate ion pair as a modifier have been fabricated to determine dabigatran etexilate in pure and pharmaceutical dosage form. The modified electrodes ion selective carbon paste electrode and ion selective pencil graphite electrode showed fast and linear response within a concentration range of 1.0 × 10?5 to 1.0 × 10?2 M and 1.0 × 10?6 to 1.0 × 10?2 M with a detection limit of 4.36 × 10?6 M and 4.26 × 10?7 M by ISCPE and ISGPE, respectively. Electrodes are selective to dabigatran etexilate over common excipients. The present study demonstrated the determination of dabigatran etexilate in pure and pharmaceutical dosage forms with high accuracy and precision.
Dabigatran etexilateIon-selectiveValidation
Abou El-Alamin M.M.、Mohamed D.A.、Toubar S.S.
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Pharmaceutical Analytical Chemistry Department Faculty of Pharmacy Helwan University
NSTL
Elsevier
