首页|A dinorcassane-type diterpene and a steroidal saponin from Distemonanthus benthamianus Baill. (Caesalpiniaceae)

A dinorcassane-type diterpene and a steroidal saponin from Distemonanthus benthamianus Baill. (Caesalpiniaceae)

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeAs part of our search for new bioactive compounds from medicinal plants growing in Cameroon, a previously unreported dinorcassane-type diterpenoid trivially named distemonanthin (1) and a new steroidal saponin, stigmasta-5,22-dien-3-O-β-D-glucopyranosyl-(1→3)-O-β-D-glucopyranoside (2) together with ten known compounds were isolated from the ethyl acetate and n-butanol soluble fractions of the methanol extract from the stem barks of Distemonanthus benthamianus. Their structures were established using 1D and 2D NMR spectroscopy, mass spectrometry and by comparison with spectroscopic data reported in the literature. The extract, fractions and some isolated compounds were screened for their antimicrobial properties and a significant inhibition was observed only for the n-butanol fraction against Candida albicans and Candida glabrata with MICs values of 32 and 64 μg/mL, respectively.

Antimicrobial activityCaesalpiniaceaeDinorcassane-type diterpenoidDistemonanthus benthamianusSaponins

Kepdieu Tchebou R.V.、Fouedjou R.T.、Ponou B.K.、Teponno R.B.、Tapondjou L.A.、Eckhardt P.、Opatz T.、Kemkuignou B.M.、Tchuenguem R.、Dzoyem J.P.、Barboni L.

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Research Unit of Environmental and Applied Chemistry Department of Chemistry Faculty of Science University of Dschang

Johannes Gutenberg University Mainz Department of Chemistry

Department of Microbial Drugs Helmholtz Centre for Infection Research GmbH

Department of Biochemistry Faculty of Science University of Dschang

School of Science and Technology Chemistry Division University of Camerino

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2022

10.1016/j.phytol.2022.02.001

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.48
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