Potential inhibitors of microglial activation from the roots of Vernicia montana Lour
Wang, Yingjie 1Chen, Gang 1Meng, Qingqi 2Yao, Xiaohu 2Li, Yang 1Cao, Honglin 3Hou, Yue 2Zhou, Di 1Li, Ning 1Lin, Bin1
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作者信息
1. Shenyang Pharmaceut Univ
2. Northeastern Univ
3. Chinese Acad Sci
折叠
Abstract
During our continuous investigation of natural, herbal inhibitors of microglial over-activation in the Euphorbiaceae family, two plants of the Vernicia genus showed remarkable inhibitory effects on nitric oxide (NO) production in over-activated microglia. In this study, bioactivity-guided phytochemical research on the active fraction of the roots of V. montana was carried out. As a result, seven undescribed terpenoids and lignans, together with thirty-one known components, were isolated and identified using comprehensive spectral analysis. All the identified compounds were evaluated for their inhibitory effects on NO production in lipopolysaccharidestimulated BV-2 cells. Combined with our previous research on the Vernicia genus, the effective material basis of different plants and medicinal components was analyzed systematically.
NSTL
Elsevier