首页|Increased antibody titers and reduced seronegativity following fourth mRNA COVID-19 vaccination in patients with cancer
Increased antibody titers and reduced seronegativity following fourth mRNA COVID-19 vaccination in patients with cancer
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NSTL
Patients with cancer are at increased risk of severe COVID-19 disease because of immunosuppression caused by the cancer and/or cancer treatments (Ehmsen et al., 2021b; Tian et al., 2020). We and others have characterized the anti-SARS-CoV-2 immune response after two and three COVID-19 mRNA vaccinations in patients with solid and hematologic cancers and observed insufficient responses in a substantial portion following the second vaccination ((Ehmsen et al., 2021a; Gounant et al., 2022; Herishanu et al., 2022) but an improved response following the third vaccination (Ehmsen et al., 2022). We further showed that the anti-SARS-CoV-2 spike receptor binding domain (anti-S) IgG antibody titers declined rapidly within the first 3 months after both the second and third vaccination. This, in combination with high infectivity rate of COVID-19 in the population in the winter of 2021-2022, made the Health Authorities in several countries, including Denmark, recommend a fourth mRNA COVID-19 vaccination to boost the immune response in this patient group. Here, we assess alterations in antibody titers (anti-S IgG) in blood samples following a fourth mRNA vaccination from patients with solid and hematologic malignancies, and we assess the waning antibody response at 3 months following the fourth vaccination.
Sidse Ehmsen、Anders Asmussen、Stefan S. Jeppesen、Anna Christine Nilsson、Amalie Kragh、Henrik Frederiksen、Henrik J. Ditzel
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Department of Oncology, Odense University Hospital, Odense, Denmark
NSTL
