首页|Sodium caseinate-coated and beta-cyclodextrin/vitamin E inclusion complex-loaded nanoliposomes: A novel stabilized nanocarrier
Sodium caseinate-coated and beta-cyclodextrin/vitamin E inclusion complex-loaded nanoliposomes: A novel stabilized nanocarrier
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NSTL
Elsevier
The aim of the present study was the loading of beta-cyclodextrin/vitamin E (beta CD/VitE) inclusion complex in liposomes (LPs) and coating of this nanocarrier with sodium caseinate (SC). The formation of beta CD/VitE inclusion complex was approved by Fourier transforms infrared (FT-IR) spectroscopy. Three concentrations of SC (2, 4, and 6 mg/mL) were used for the coating of LPs. By considering particle size, zeta potential, and morphology, the 6 mg/mL concentration of SC was selected as the optimum concentration. The zeta potential and particle size of the coated complex-loaded LPs were +17.90 +/- 0.80 mV and 173.9 +/- 42.4 nm, respectively. The transmission electron microscopy of the coated complex-loaded LPs showed a spherical and core-shell structure. Additionally, the encapsulation efficiency of VitE in the LPs as the form of beta CD/VitE inclusion complex was 83.8 +/- 3.7%. The formation of hydrogen-bonding interactions among complex, LPs, and SC was confirmed by FT-IR spectroscopy. The coating of LPs with SC significantly improved their thermal stability. Moreover, the coated LPs exhibited a better-sustained release profile than the uncoated LPs in the simulated gastrointestinal condition. In conclusion, the developed nanocarrier has promising advantages and potential applications in the nutraceutical and medical fields.
NSTL
Elsevier
