首页|A NEW URSANE-TYPE TRITERPENOID FROM THE LEAVES OF Rhododendron dauricum WITH CYTOTOXIC ACTIVITY
A NEW URSANE-TYPE TRITERPENOID FROM THE LEAVES OF Rhododendron dauricum WITH CYTOTOXIC ACTIVITY
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NSTL
A new ursane-type triterpenoid,20-taraxastene-22α-methoxy-3P-ol(1)together with nine known triterpenoids(2-10),was isolated from the leaves of Rhododendron dauricum L.Their structures were established from spectroscopic data(ID,2D NMR,and HR-ESI-MS)and comparison with reported values.Among the isolates,compounds 1 and 8 were found in the family Ericaceae for the first time,and compounds 5,6,and 10 from this species for the first time.All the isolated compounds were evaluated for their cytotoxic activities against three human cancer cells;compound 1 exhibited better cytotoxic activity against A549,HeLa,and SK-Hepl cells than the other compounds with IC_(50)values of 34.04 ± 1.01,64.04 ± 1,75,and 44.04 ± 0.05 μМ,respectively.
Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules,Ministry of Education,Yanbian University College of Pharmacy,133002,Yanji,P.R.China
Yanbian University Hospital,133000,Yanji,P.R.China
NSTL
