首页|Association between risk of obstructive sleep apnea, inflammation and cognition after 45 years old in the Canadian Longitudinal Study on Aging

Association between risk of obstructive sleep apnea, inflammation and cognition after 45 years old in the Canadian Longitudinal Study on Aging

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  • NSTL
  • Elsevier
Background: The association between obstructive sleep apnea and cognitive functioning is not yet fully understood and could be influenced by factors such as sex, age and systemic inflammation. We deter-mined the sex-and age-specific association between obstructive sleep apnea risk and cognitive per-formance, and the influence of systemic inflammation on this association. Methods: We included 25,899 participants from the Canadian Longitudinal Study of Aging compre-hensive cohort, aged 45-85 years (51% women). We conducted sex-and age-specific (45-59; 60-69; >70) general linear models between obstructive sleep apnea risk and cognitive scores, and tested the moderating and mediating effects of high-sensitivity C-reactive protein levels. Obstructive sleep apnea risk was estimated by combining the STOP and whole-body fat percentage. Cognitive tests assessed episodic verbal memory, executive functions and psychomotor speed. Levels of high-sensitivity C-reactive protein were obtained through blood samples. Results: Higher obstructive sleep apnea risk was associated with poorer episodic memory in women aged 45-59 years, and poorer executive function (p < 0.05 on multiple tests) in women aged 45-59 and 60-69 years. No such association was found in men. High-sensitivity C-reactive protein levels mediated some associations between obstructive sleep apnea risk and executive function in women and men aged <70 years.Conclusions: Being at high-risk for obstructive sleep apnea is associated with poorer cognition in women aged <70 years. These associations were partly mediated by systemic inflammation. These results un-derscore the importance of obstructive sleep apnea diagnosis, treatment and appropriate follow-up, particularly in middle-aged women who might already show signs of early cognitive impairments.(c) 2022 Elsevier B.V. All rights reserved.

Sleep-disordered breathingAgingC-reactive proteinCognitionSYSTEMIC INFLAMMATIONNORMATIVE DATAMASS INDEXFAT MASSQUESTIONNAIREINHIBITIONSTATEMENTVALIDITY

Legault, Julie、Moullec, Gregory、Martineau-Dussault, Marie-Eve、Baltzan, Marc、Cross, Nathan、Thien Thanh Dang-Vu、Gervais, Nicole、Einstein, Gillian、Hanly, Patrick、Ayas, Najib、Lorrain, Dominique、Kaminska, Marta、Gagnon, Jean-Francois、Lim, Andrew、Carrier, Julie、Gosselin, Nadia、Thompson, Cynthia

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Res Ctr,CIUSSS Nord Ile de Montreal

Mt Sinai Hosp Ctr

Ctr Rech,CIUSSS Ctr Sud Ile de Montreal

Rotman Res Inst,Baycrest Hlth Sci

Dept Psychol,Univ Toronto

Cumming Sch Med,Univ Calgary

Dept Med,Univ British Columbia

Univ Inst Geriatr Sherbrooke,CIUSSS Estrie CHUS

Hlth Ctr,McGill Univ

LC Campbell Cognit Neurol Res Unit,Sunnybrook Res Inst

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2022

10.1016/j.sleep.2022.02.006

Sleep medicine

Sleep medicine

SCI
ISSN：1389-9457
年,卷(期)：2022.91
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