首页|The synergistic effects of coupling Au nanoparticles with an alkynyl Co(II) phthalocyanine on the detection of prostate specific antigen

The synergistic effects of coupling Au nanoparticles with an alkynyl Co(II) phthalocyanine on the detection of prostate specific antigen

扫码查看
原文链接
  • NSTL
  • Elsevier
Prostate specific antigen (PSA) aptasensors are fabricated using a novel asymmetrically substituted Co phthalocyanine (CoPc), gold nanoparticles (AuNPs) and PSA-specific antigen. The fabricated aptasensors are: GCE-AuNPs-Aptamer, GCE@CoPc-Aptamer and GCE-AuNPs@CoPc-Aptamer (GCE = glassy carbon electrode). The fabricated sensors are characterized at each modification step to monitor the changes occurring at the sensor surface. Concentration studies were carried out using differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) to determine detection limits. All the fabricated aptasensors were found to be highly specific and selective but the GCE-AuNPs@CoPc-Aptamer nanoconjugate performed the best. The aptasensors were also tested in spiked serum samples and detection limits, as well as % recoveries were determined. The results obtained showed that the GCE-AuNPs@CoPc-Aptamer has the potential to be used for clinical studies as the results agree with those obtained for detection of PSA in buffer.

Prostate specific antigenGold nanoparticlesCobalt phthalocyanineAptasensorElectrochemical impedance spectroscopyDifferential pulse voltammetryGOLD NANOPARTICLESCLICK CHEMISTRYELECTROCHEMICAL-BEHAVIORCARBON NANOTUBESQUANTUM DOTSELECTRODESAPTASENSORREDUCTIONCANCERPSA

Nxele, Siphesihle Robin、Nkhahle, Reitumetse、Nyokong, Tebello

展开 >

Rhodes Univ

2022

10.1016/j.talanta.2021.122948

Talanta

Talanta

EISCI
ISSN：0039-9140
年,卷(期)：2022.237
  • 5
  • 56