The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as “being a multilayered condensate,” and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.
Alan Tartakoff、Patrick DiMario、Eduard Hurt、Brian McStay、Vikram Govind Panse、David Tollervey
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Case Western Reserve University, Cleveland, Ohio 44106, USA
NSTL
