首页|Context-driven automatic subgraph creation for literature-based discovery

Context-driven automatic subgraph creation for literature-based discovery

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Background: Literature-based discovery (LBD) is characterized by uncovering hidden associations in non-interacting scientific literature. Prior approaches to LBD include use of: (I) domain expertise and structured background knowledge to manually filter and explore the literature, (2) distributional statistics and graph-theoretic measures to rank interesting connections, and (3) heuristics to help eliminate spurious connections. However, manual approaches to LBD are not scalable and purely distributional approaches may not be sufficient to obtain insights into the meaning of poorly understood associations. While several graph-based approaches have the potential to elucidate associations, their effectiveness has not been fully demonstrated. A considerable degree of a priori knowledge, heuristics, and manual filtering is still required.

Literature-based discovery (LBD)Graph miningPath clusteringHierarchical agglomerative clusteringSemantic relatednessMedical Subject Headings (MeSH)

Bodenreider, Olivier、Cameron, Delroy、Kavuluru, Ramakanth、Rindflesch, Thomas C.、Sheth, Amit P.、Thirunarayan, Krishnaprasad

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Natl Lib Med, Bethesda, MD 20894 USA

Wright State Univ, Ohio Ctr Excellence Knowledge Enabled Comp Kno E, Dayton, OH 45435 USA

Univ Kentucky, Div Biomed Informat, Lexington, KY 40506 USA

2015

Journal of biomedical informatics.

Journal of biomedical informatics.

ISSN:1532-0464
年,卷(期):2015.54
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