首页|Smartphone-assisted electrochemical sensor for reliable detection of tyrosine in serum

Smartphone-assisted electrochemical sensor for reliable detection of tyrosine in serum

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  • NSTL
  • Elsevier
Point-of-care devices have attracted a huge interest by the scientific community because of the valuable potentiality for rapid diagnosis and precision medicine through cost-effective and easy-to-use devices for on-site measurement by unskilled personnel. Herein, we reported a smartphone-assisted electrochemical device consisted of a screen-printed electrode modified with carbon black nanomaterial and a commercially available smartphone potentiostat i.e. EmStat3 Blue, for sensitive detection of tyrosine. Once optimized the conditions, tyrosine was detected in standard solutions by square wave voltammetry, achieving a linear range comprised between 30 and 500 mu M, with a detection limit equal to 4.4 mu M. To detect tyrosine in serum, the interference of another amino acid i.e. tryptophan was hindered using a sample treatment with an extraction cartridge. The agreement of results analyzing serum samples with HPLC reference method and with the developed smart sensing system demonstrated the suitability of this smartphone-assisted sensing tool for cost-effective and rapid analyses of tyrosine in serum samples.

Square wave voltammetryExtraction cartridgeScreen-printed electrodeCarbon black nanomaterialBiological fluidTyrosineMASS-SPECTROMETRY METHODSPECTROPHOTOMETRIC DETERMINATIONKINASE INHIBITORSHOMOGENTISIC ACIDCARBON NANOTUBESGRAPHENETRYPTOPHANELECTRODE(BIO)SENSORSPARACETAMOL

Goffredo, Bianca Maria、Moscone, Danila、Arduini, Fabiana、De Lellis, Benedetta、Mazzaracchio, Vincenzo、Suprun, Elena、Massoud, Renato、Fiore, Luca

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IRCCS Bambino Gesu Pediat Hosp

Univ Roma Tor Vergata

Inst Biomed Chem

2022

10.1016/j.talanta.2021.122869

Talanta

Talanta

EISCI
ISSN：0039-9140
年,卷(期)：2022.237
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