ETHANOL-INDUCED SINGLE-STRAND DNA BREAKS IN RAT BRAIN CELLS

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外文摘要：Male Sprague-Dawley rats were intubated with 4 g/kg body weight of ethanol (in a 20%, v/v, water solution). Brain cells were analyzed for single-strand DNA breaks at various post-ethanol administration time points using an alkaline microgel electrophoresis assay. Results showed a significant increase in single-strand DNA breaks in brain cells that peaked at approx. 4 h and returned to control level within 6 h after ethanol administration.

外文关键词：

EthanolBrain cellAlkaline microgel electrophoresisSingle strandRadical generationLipid peroxidationNeuronal lossAlcoholAcetaldehydeConsumptionIronMetabolismImpairmentExposure

作者：

Singh NP、Lai H、Khan A

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作者单位：

Singh NP, UNIV WASHINGTON, SCH MED, DEPT PSYCHIAT & BEHAV SCI, BOX 356560, SEATTLE, WA 98195, USA

出版年：

1995

Mutation research

ISSN：0165-1218

年,卷(期)：1995.345(3/4)