首页|Six new dammarane-type triterpene saponins from the processed leaves of Panax notoginseng

Six new dammarane-type triterpene saponins from the processed leaves of Panax notoginseng

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? 2022 Phytochemical Society of EuropeSix new dammarane-type triterpenoid saponins, notoginsenosides SFt5–SFt10 (1–6) were isolated from the processed leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eight known notoginsenosides (7–14), fourteen known ginsenosides (15?28), two known vinaginsenosides (29?30), and one known gypenoside (31). Their structures were established by detailed spectroscopic analysis (NMR, UV, IR, HRESI-MS) and acidic hydrolysis. Four compounds notoginsenoside SFt1 (7), ginsenosides Rg5 (17), C-Mc (23) and 20(R)–Rg3 (25) have significant protective effects against L-glutamate-induced SH–SY5Y nerve injury (10 μM).

GinsenosideNeuroprotection bioassaysNotoginsenosidePanax notoginseng

Zhang M.、Sun X.、Ren R.、Su L.、Xu M.、Li H.、Zheng L.

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Faculty of Life Science and Technology Kunming University of Science and Technology

National Engineering Research Center for Modernization of Traditional Chinese Medicine Weihe Pharmaceutical Co. Ltd

2022

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN:1874-3900
年,卷(期):2022.49
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