首页|Polycations and polyanions in SARS-CoV-2 infection

Polycations and polyanions in SARS-CoV-2 infection

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  • NSTL
  • Elsevier
We hypothesize that polycations， such as nuclear histones， released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms: (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane， thereby enhancing receptor-mediated entry。 (B) Binding to the virus particles， thereby inducing opsonin-mediated endocytosis。 (C) Adding to the cytotoxicity， in conjunction with oxidants， cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system。 These effects may be alleviated by the administration of negatively charged polyanions such as heparins and heparinoids。

COVID-19SARS-CoV-2TherapyNeutrophilsPolycationsPolyanionsHeparin

Ginsburg, I、Fibach, E.

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Hebrew Univ Jerusalem, Fac Dent Med, Hadassah Sch Med, Ein Kerm Campus, Jerusalem, Israel

Hebrew Univ Jerusalem, Dept Hematol, Hadassah Sch Med, Ein Kerm Campus, Jerusalem, Israel

2021

10.1016/j.mehy.2020.110470

Medical hypotheses

Medical hypotheses

SCI
ISSN：0306-9877
年,卷(期)：2021.146
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