首页|A novel polarity-sensitive fluorescent probe for lighting up lipid droplets and its application in discriminating dead and living zebrafish
A novel polarity-sensitive fluorescent probe for lighting up lipid droplets and its application in discriminating dead and living zebrafish
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NSTL
In the present study,we developed a novel fluorescent chemosensor with a hybrid structure of 3-pyridinonitriie-coumarin derivatives by molecular design strategy that can effectively label intracellular lipid droplets.Interestingly,the probe ATOP-LD also exhibited polarity-sensitive properties,which may be attributable to its own strong electron-giving and electron-absorbing moieties.In addition,the probe exhibited excellent interference resistance,pH stability and low biotoxicity and had been successfully applied to cell imaging.Also,probe ATOP-LD could discriminate dead and living zebrafish or its embryos.These satisfactory properties prove that the probe is useful and possesses great potential for application.
State Key Laboratory of Biobased Material and Green Papermaking,Key Laboratory of Paper Science and Technology of Ministry of Education,Faculty of Light Industry,Qi Lu University of Technology(Shandong Academy of Sciences),Jinan,250353,PR China
NSTL
