首页|DESIGN, SYNTHESIS, AND CHARACTERIZATION OF SOME NOVEL THIAZOLIDINE-2,4-DIONE DERIVATIVES AS ANTIDIABETIC AGENTS
DESIGN, SYNTHESIS, AND CHARACTERIZATION OF SOME NOVEL THIAZOLIDINE-2,4-DIONE DERIVATIVES AS ANTIDIABETIC AGENTS
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NSTL
Polskie Towarzystwo Farmaceutyczne
The number of thiazolidine-2,4-dione compounds is quite well established to reduce blood glucose levels. The current study focuses on designing and synthesizing novel thiazolidine-2,4-dione deriva-tives as antidiabetic agents. Initially, thiourea was reacted with chloroacetic acid to yield the intermediate compound 2-iminothiazolidine-4-one, which was then converted into compound thiazolidine-2,4-dione in an acidic medium with reflux. The second step is to prepare 5-ary1idene-2,4-thiazolidinedione via the Knoevenagel condensation of vanillin with thiazolidine-2,4-dione, which is catalyzed by piperidine. Finally, a series of novel azo derivatives were synthesized by an azo coupling reaction of 5-arylidene-2,4-thiazolidinedione with aromatic amines. Physical methods (gauge melting point), thin-layer chromatography (TLC), and spectroscopic methods (IR, H-1-NMR, and Mass) were used to investigate compounds. The antidiabetic activity of the prepared derivatives was investigated using a sucrose-loaded model. The experiment revealed an excellent result in terms of blood glucose reduction.
NSTL
Polskie Towarzystwo Farmaceutyczne
