首页|Discovery of Potent PROTACs for the Potential Treatment of Leukemia
Discovery of Potent PROTACs for the Potential Treatment of Leukemia
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NSTL
Amer Chemical Soc
? 2022 American Chemical Society. All rights reserved.Janus kinases family PROTACs have been developed that recruit inhibitor of apoptosis protein leading to proteasomal degradation. JAK2 is involved in multiple cytokine pathways, including IL-6-mediated signaling and associated granulocyte-macrophage colony-stimulating factor, which are critical for different physiological processes like hematopoiesis, bone metabolism, and differentiation of B-cells.
NSTL
Amer Chemical Soc
