Ilex(Aquifoliaceae)species are distributed widely in the People's Republic of China,and some are used extensively in folk medicine.For example,Ilex rotunda is antipyretic and an antidote and is used for the treatment of the common cold,tonsillitis,and stomach and intestinal ukers.L pubescens is used for the treatment of coronary disease,myocardial infarction,dysentery,and erysipelas.L comuta and I.latifolia are used for the treatment of headache,toothache,bloodshot eyes,and tinnitus(1).Previous studies on the Ilex genus have led to the isolation of triterpenes,triterpene glycosides(2),hemiterpene glycosides(3),phenolic compounds(4),and flavonoids(5).In the present study on the chemical components of the leaves of Ilex latifolia Thunb.,13 compounds were isolated.A methanolic extract of the leaves of I.latifolia was concentrated to obtain a residue,and it was partitioned between CH2CI2 and H2O.The aqueous layer was extracted with n-BuOH.The n-BuOH layer was concentrated and subjected to chromatography.As a result,13 compounds,including nine isoquinoline alkaloids,northalifoline(1)(6),thalifoline(2)(6),corydaldine(3)(7),and N-methykoiydaldine(4)(8),oxyberberine(5)(9),berberine(6)(10),palmathe(7)(11),jatrorrhizine(8)(12),and columbamine(9)(13),and four benzenoids,p-hydroxybenzaldehyde(6),p-hydroxybenzoic acid(6),3,4-dimethoxy benzoic apid(6),and syringic acid(6)were isolated All of these compounds were isolated for the first time from this source.
C.Y Chen、С L.Као、Н.С Yeh
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School of Medical and Health Sciences,Fooyin University,Ta-Liao,83102,Kaohsiung,Taiwan
Tzu Hui Institute of Technology,Pingtung County,Taiwan
NSTL
