首页|Antidiabetic triterpenoids from the leaves of Paeonia suffruticosa and Paeonia delavayi
Antidiabetic triterpenoids from the leaves of Paeonia suffruticosa and Paeonia delavayi
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeThree new nor-oleanane triterpenoids, paeonenoides I-K (1-3), together with 13 known triterpenoids including nor-oleanane, oleanane, ursane, and cycloartane types, were isolated from the leaves of Paeonia suffruticosa and P. delavayi. The structures of the new compounds were elucidated with the aid of HRESIMS, 1D and 2D NMR, IR, and [α]D spectroscopic methods. Nine compounds (5-6, 8-11, 13-14 and 16) showed inhibition against PTP1B with IC50 values ranging from 36.5 to 192.6 μM, six compounds (5-6, 8-10 and 14) exhibited inhibitory activity against GPa with IC50 values ranging from 39.8 to 108.0 μM, and five compounds (1, 6, 10, 15 and 16) could significantly stimulate GLP-1 secretion by 100.2–313.4% (20 μM). Docking study demonstrated that compounds 5 and 6 strongly bonded with Gpa and PTP1B by salt bridges, hydrogen bonds and hydrophobic interactions, verifying the importance of carboxyl and hydroxyl groups. Especially, compounds 5 and 14 could simultaneously inhibit PTP1B and GPa with IC50 values of 57.8, 47.9 μM and 39.8, 45.2 μM, and compounds 6 and 10 could stimulate GLP-1 secretion by 293.6% and 313.4% at 20 μM.
GLP-1 stimulationPaeonenoides I-KPaeonia delavayiPaeonia suffruticosaPTP1B and GPa inhibition
Pan Y.、Wu S.-L.、Huang X.-Y.、Hu J.、Huang Q.、Ma Y.-B.、Zhang X.-M.、Geng C.-A.
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State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences
Yunnan Key Laboratory of Natural Medicinal Chemistry
NSTL
Elsevier
