首页|Cutaneous soft tissue sarcomas: survival-related factors

Cutaneous soft tissue sarcomas: survival-related factors

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  • NSTL
  • Springer Nature
Cutaneous sarcomas are a heterogeneous group of rare mesenchymal neoplasms representing less than 1% of malignant tumors. Histology report remains the cornerstone for the diagnosis of these tumors. The most important clinicopathologic parameters related to prognosis include larger tumor size, high mitotic index, head and neck location, p53 mutations, depth of infiltration and histological grade, vascular and perineural invasion as well as the surgical margins status. Applying advanced biopsy techniques might offer more precise assessment of surgical margins, which constitutes a significant precondition for the management of these tumors. The management of cutaneous soft tissue sarcomas requires a multidisciplinary approach. Surgery remains the standard treatment, nonetheless adjuvant therapy may be required, consisting of radiotherapy, chemotherapy, and molecular targeted therapies to improve treatment outcomes. The role of molecular profiling in the treatment of uncontrolled disease is promising, but it may be offered to a relatively small proportion of patients and its use is still considered experimental in this setting. Due to the rarity of the disease, there is a need for knowledge and experience to be shared, pooled, organized and rationalized so that recent developments in medical science can have a major impact on the disease course. Multicenter clinical trials are needed to improve the care of patients with cutaneous sarcomas.

CutaneousSarcomasFactorsBiopsyTreatmentSurvivalRecurrenceMOHS MICROGRAPHIC SURGERYMALIGNANT FIBROUS HISTIOCYTOMALONG-TERM OUTCOMESDERMATOFIBROSARCOMA PROTUBERANSATYPICAL FIBROXANTHOMAPROGNOSTIC-FACTORSKAPOSI-SARCOMAFROZEN-SECTIONANGIOSARCOMASKIN

Charalampakis, Nikolaos、Schizas, Dimitrios、Cuccia, Francesco、Alongi, Filippo、de Mello, Ramon Andrade、Iliadis, George、Kamposioras, Konstantinos、Mazonakis, Michalis、Tolia, Maria、Gkantaifi, Areti、Diamantis, Alexandros、Mauri, Davide、Nixon, Ioanna、Kyriazoglou, Anastassios、Baloyiannis, Ioannis、Tsoukalas, Nikolaos

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Oncol Clin,Metaxa Canc Hosp

Laikon Gen Hosp,Natl & Kapodistrian Univ Athens

Adv Radiat Oncol Dept,IRCCS SacroCuore Don Calabria

Div Med Oncol,Fed Univ Sao Paulo UNIFESP

Radiotherapy Dept,Interbalkan Med Ctr

Dept Med Oncol,Christie NHS Fdn Trust

Fac Med,Univ Crete

Univ Hosp,Univ Crete

Radiotherapy Dept,Theagenio Anticanc Hosp Thessaloniki

Dept Gen Surg,Univ Hosp Larisa

Dept Med Oncol,Univ Hosp Ioannina

Beatson West Scotland Canc Ctr

Propaedeut Dept Med 2,Attikon Univ Hosp

Oncol Clin,401 Gen Mil Hosp

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2022

10.1007/s00403-021-02268-1

Archives of dermatological research.

Archives of dermatological research.

ISSN：0340-3696
年,卷(期)：2022.314(7)
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