首页|New piericidin derivatives from the marine-derived streptomyces sp. SCSIO 40063 with cytotoxic activity
New piericidin derivatives from the marine-derived streptomyces sp. SCSIO 40063 with cytotoxic activity
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NSTL
Taylor & Francis
Abstract Two new piericidins A5 (1) and G1 (2), a previously synthesized piericidin G2 (3), and two known piericidins A1 (4) and A2 (5) were isolated from the marine-derived Streptomyces sp. SCSIO 40063. The structures of 1-5 were elucidated by HRESIMS, 1?D, 2?D NMR data analyses and comparisons with the known compounds. Compound 2 showed moderate cytotoxicities against four human tumor cell lines SF-268, MCF-7, HepG2 and A549 with IC50 values between 10.0 and 12.7?μM.
NSTL
Taylor & Francis
