Polyalthia is one of the largest genera in the Annonaceae family and has been widely used in folk medicine for the treatment of rheumatic fever,gastrointestinal uker,and generalized body pain(1).Polyalthia mmphii(Blume ex Hensch.)Mern is locally known as'merpadi,'and is used in some places in Indonesia to treat skin disease(2).We have recently reported on the chemical compositions of the essential oil from this species(3).As part of our continuing search to explore natural compounds from Polyalthia species,we have investigated the phytochemical study of the leaves of P.mmphii.Fractionation and purification of the extracts afforded four flavones:5,7-dimethoxyflavone(1),4',5,7-trimethoxyflavone(2),5-hydroxy-7-methoxyflavone(3),4'-hydroxy-5,7-dimethoxyflavone(4),together with lupeol(5),taraxerol(6),and β-sitosterol(7).Their structures were established on the basis of spectroscopic analysis and chemical evidence.To the best of our knowledge,all the compounds were isolated for the first time from this species.
Natasa Mohd Shakri、Wan Mohd Nuzul Hakimi Wan Salleh、Shamsul Khamis
展开 >
Department of Chemistry Faculty of Science and Mathematics,Universiti Pendidikan Sultan Idris,35900 Tanjong Malim,Perak,Malaysia
School of Environmental and Natural Sciences,Faculty of Science and Technology,Universiti Kebangsaan Malaysia,43600 Bangi,Selangor,Malaysia
NSTL
