首页|Cytotoxic isoflavonoids from the roots of Desmodium velutinum (Willd.) DC

Cytotoxic isoflavonoids from the roots of Desmodium velutinum (Willd.) DC

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  • NSTL
  • Elsevier
? 2022 Phytochemical Society of EuropeA phytochemical investigation on the roots of Desmodium velutinum (Willd.) DC. afforded five pterocarpans, desmovelutins A–E and two isoflavans, desmovelisoflavans A and B, together with seven known compounds. Their structures were established by spectroscopic methods. Several isolated compounds were evaluated for their cytotoxic activities against four human cancer cell lines (A549, HepG2, HuCCA-1, and MOLT-3). Desmovelutin D, desmovelisoflavan A, 1-methoxyerythrabyssin II, gangetin, gangetial, and desmodin showed significant cytotoxicity against MOLT-3 cells with IC50 values in the range of 3.4?27.9 μM.

Cytotoxic activityDesmodium velutinumFabaceaeIsoflavanPterocarpan

Kaweetripob W.、Thongnest S.、Boonsombat J.、Kheawchaum S.、Mahidol C.、Prawat H.、Ruchirawat S.

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Chulabhorn Research Institute

2022

10.1016/j.phytol.2022.01.018

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.48
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