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Mini reviews in medicinal chemistry
Bentham Science Publishers
Mini reviews in medicinal chemistry

Bentham Science Publishers

1389-5575

Mini reviews in medicinal chemistry/Journal Mini reviews in medicinal chemistry
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    Meet the Editorial Board Member

    Mengchao Cui
    1页
      原文链接:
    • NSTL

    Acanthospermum hispidum DC: An Updated Review on Phytochemistry and Biological Activities

    Ewelyn dos SantosJanaina MachadoMagda FerreiraLuiz Soares...
    17页
    查看更多>>摘要：Background: Acanthospermum hispidum DC is a medicinal plant present in America, Africa, Australia, India, Hawaii, and Brazil. In Brazil, the species is used in the treatment of gastrointestinal, respiratory disorders and has expectorant action. In the literature, there are studies on the chemical composition of the species, with reports of the presence of alkaloids, flavonoids, hydrolyzable tannins, terpenes, and steroids. In addition, several studies have reported in vitro and in vivo studies that prove the biological properties of extracts and compounds isolated from different organs of the A. hispidum plant, including hepatoprotectors, antioxidants, antimicrobials and antiparasitic. Objective: The objective of this review is to update the knowledge about the phytochemical, pharmacological and toxicity aspects of A. hispidum, and to contribute to the recognition of the species and direct new studies. Methods: An extensive bibliographic search was conducted in different scientific databases. Results: The presence of different chemical constituents in A. hispidum has been identified, among these constituents are flavonoids, tannins, terpenes, and steroids. Additionally, antimicrobial and antiparasitic activities were mainly attributed to the species, and other activities not previously described were presented, such as anticholinesterase, antioxidant, hepatoprotective, and hypoglycemic, all based on results of in vitro and in vivo studies. Finally, no reports of toxic effects were found in the in vitro and in vivo tests. After analyzing the articles, it was evidenced that other experiments with different models using animals are essential to evaluate the possible mechanisms of action of the extracts and compounds isolated of A. hispidum. Conclusion: Therefore, this review may contribute to the recognition of the importance of A. hispidum and its potential as a medicinal plant and may also guide the conduct of future research regarding the constituents, biological activities, and toxicity of the species.
      原文链接:
    • NSTL
    • Bentham Science Publ Ltd

    An Overview of Synthesis and Biological Activity of Dihydropyrimidine Derivatives

    Anshu DudheRupesh DudheOmji PorwalGayatri katole...
    28页
    查看更多>>摘要：Dihydropyrimidine derivatives are the most important scaffolds due to structural similarities with natural products; it is a heterocyclic compound. The chemistry of Dihydropyrimidine is a growing field. Various reaction schemes for the preparation of Dihydropyrimidines produce different biological effects and offer vast scope in the field of medicinal chemistry. This article's goal is to analyze the work that reported the recent chemistry and pharmacological activities of dihydropyrimidine derivatives.
      原文链接:
    • NSTL
    • Bentham Science Publ Ltd

    Research Progress on the Natural Product Aloperine and Its Derivatives

    Yu ChengAbdur RaufXiandao Pan
    14页
    查看更多>>摘要：In this review, an effort towards presenting an all-around account of the recent progress on the natural product, aloperine, is made, and the antivirus structure-activity relationship of its derivatives is also summarized comprehensively. In addition, the principal pharmacological effects and corresponding molecular mechanisms of aloperine are discussed. Some new structural modifications of aloperine are also given, which might provide brief guidance for further investigations on the natural product aloperine.
      原文链接:
    • NSTL
    • Bentham Science Publ Ltd

    Some Scaffolds as Anti-leishmanial Agents: A Review

    Thatikayala MahenderWadhwa PankajSingh KumarVaidya Ankur...
    15页
    查看更多>>摘要：Leishmaniasis is a parasitic infectious neglected tropical disease transmitted to humans by the parasites of Leishmania species. Mainly, three types of leishmaniases are usually observed: visceral (VL), cutaneous (CL), and mucocutaneous leishmaniasis. In many western countries, almost 700,000 to 1 million people suffer from leishmaniasis, and it is estimated that around 26000 to 65000 deaths occur from leishmaniasis. Few drugs are available for its treatment; however, none of them are ideal for leishmaniasis due to long treatment, discomfort mode of administration, risk of high-level toxicity, high resistance, etc. Hence, so many patients are unable to take complete treatment due to the high drug resistance. The present review will focus on antileishmanial activity of reported derivatives of betacarboline, chalcone, azole, quinoline, quinazoline, benzimidazole, benzadiazapine, thiaazoles, semicarbazone, and hydontoin analogues. We believe that this present study will be helpful for researchers to design new antileishmanial agents.
      原文链接:
    • NSTL
    • Bentham Science Publ Ltd

    Anticancer Potential of Naringenin, Biosynthesis, Molecular Target, and Structural Perspectives

    Om PrakashRuchi SinghNamrata SinghShazia Usmani...
    12页
    查看更多>>摘要：Numerous novel medicinal agents isolated from plant sources were used as indigenous remedies for the management and treatment of various types of cancer diseases. Naringenin is a naturally occurring flavanone glycoside, and aglycone (genin) moiety of naringin, predominantly found in citrus and grapefruits, has emerged as a potential therapeutic agent for the management of a variety of diseases. A number of scientific papers have been published on naringenin describing its detailed studies and its therapeutic application in different diseases. The current study highlights a comprehensive study on naringenin concerning its biosynthesis, molecular targets/pathways involved in carcinogenesis, mechanism of actions (MOAs), and structure-activity relationships (SARs), and patents granted have been highlighted. Naringenin and its derivatives have great anti-cancer activity due to their inhibitory potential against diverse targets, namely ABCG2/P-gp/BCRP, 5a-reductase, 17- bhydroxysteroid dehydrogenase, aromatase, proteasome, HDAC/Situin-1, VEGF, VEGFR-2 kinase, MMP-2/9, JAK/STAT signaling pathways, CDC25B, tubulin, topoisomerase-II, cathepsin-K, Wnt, NF-kB, B-Raf and mTOR, etc. With the in-depth knowledge of molecular targets, structural intuition, and SARs, the current study may be beneficial to design more potent, safe, effective, and economic anti-cancer naringenin. This has been concluded that naringenin is a promising natural product for the management and therapy of cancer. Further evolution for pharmacological importance, clinical research, and trials are required to manifest its therapeutic action on metabolic syndrome in the human community.
      原文链接:
    • NSTL
    • Bentham Science Publ Ltd

    Methyl-linked Pyrazoles: Synthetic and Medicinal Perspective

    Bijender SinghRamesh KatariaVinod KumarTulika Sharma...
    35页
    查看更多>>摘要：Pyrazoles, an important and well-known class of the azole family, have been found to show a large number of applications in various fields, especially medicinal chemistry. Pyrazole derivatives, particularly methyl-substituted pyrazoles, have been reported as potent medicinal scaffolds that exhibit a wide spectrum of biological activities. The present review is an attempt to highlight the detailed synthetic approaches for methyl-substituted pyrazoles along with an in-depth analysis of their respective medical significances till March 2021. It is hoped that literature sum-up in the form of present review article would certainly be a great tool in assisting medicinal chemists in generating new leads possessing pyrazole nucleus with high efficacy and less microbial resistance.
      原文链接:
    • NSTL
    • Bentham Science Publ Ltd

    A Review: Discovering 1,3,4-oxadiazole and Chalcone Nucleus for Cytotoxicity / EGFR Inhibitory Anticancer Activity

    Shashikant BhandariShital Patil
    16页
    查看更多>>摘要：Introduction: Cancer is reported to be one of the most life-threatening diseases. Major limitations of currently used anticancer agents are drug resistance, very small therapeutic index, and severe, multiple side effects. Objective: The current scenario necessitates developing new anticancer agents, acting on novel targets for effectively controlling cancer. The epidermal growth factor receptor is one such target, which is being explored for 1,3,4-oxadiazole and chalcone nuclei. Methods: Findings of different researchers working on these scaffolds have been reviewed and analyzed, and the outcomes were summarized. This review focuses on Structure-Activity Relationship studies (SARs) and computational studies of various 1,3,4-oxadiazole and chalcone hybrids/ derivatives reported as cytotoxic/EGFR-TK inhibitory anticancer activity. Result and Conclusion: 1,3,4-oxadiazole and chalcone hybrids/derivatives with varied substitutions are found to be effective pharmacophores in obtaining potent anticancer activity. Having done a thorough literature survey, we conclude that this review will surely provide firm and better insights to the researchers to design and develop potent hybrids/derivatives that inhibit EGFR.
      原文链接:
    • NSTL
    • Bentham Science Publ Ltd

    Pharmacological Actions and Underlying Mechanisms of Catechin: A Review

    Aadrika BaranwalPunita AggarwalAmita RaiNitesh Kumar...
    13页
    查看更多>>摘要：Background: Catechin is a phytochemical and is a major component of our daily use beverages, which has shown great potential in improving general health and fighting against several medical conditions. Clinical studies have confirmed its effectiveness in conditions ranging from acute upper respiratory tract infection, neuroprotection, to cardio-protection effects. Though most studies relate their potential to anti-oxidative action and radical scavenging action, still the mechanism of action is not clearly understood. Objective: The present review article is focused on addressing various pharmacological actions and underlying mechanisms of catechin. Additionally, we will try to figure out the major adverse effect and success in trials with catechin and lead to a conclusion for its effectiveness. Methods: This review article is based on the recent/ most cited papers of PubMed and Scopus databases. Description: Catechin can regulate Nrf2 and NFkB pathways in ways that impact oxidative stress and inflammation by influencing gene expression. Other pathways like MAPKs and COMT and receptor tyrosine kinase are also affected by catechin and EGCG that alter their action and barge the cellular activity. This review article explored the structural aspect of catechin and its different isomers and analogs. It also evaluated its various therapeutic and pharmacological arrays. Conclusion: Catechin and its stereo-isomers have shown their effectiveness as anti-inflammatory, anti-diabetic, anti-cancer, anti-neuroprotective, bactericidal, memory enhancer, anti-arthritis, and hepato-protective mainly through its activity to alter the pathway by NF-κB, Nrf-2, TLR4/NF-κB, COMT, and MAPKs.
      原文链接:
    • NSTL
    • Bentham Science Publ Ltd