查看更多>>摘要：Abstract Microalgae and cyanobacteria (blue‐green algae) are used as food by humans. They have gained a lot of attention in recent years because of their potential applications in biotechnology. Microalgae and cyanobacteria are good sources of many valuable compounds, including important biologically active compounds with antiviral, antibacterial, antifungal, and anticancer activities. Under optimal growth condition and stress factors, algal biomass produce varieties of potential bioactive compounds. In the current review, bioactive compounds production and their remarkable applications such as pharmaceutical and nutraceutical applications along with processes involved in identification and characterization of the novel bioactive compounds are discussed. Comprehensive knowledge about the exploration, extraction, screening, and trading of bioactive products from microalgae and cyanobacteria and their pharmaceutical and other applications will open up new avenues for drug discovery and bioprospecting.
Hoda HosseiniHareb M. Al‐JabriNavid R. MoheimaniSimil A. Siddiqui...
14页
查看更多>>摘要：Abstract The increase in the human population causes an increase in the demand for nutritional supplies and energy resources. Thus, the novel, natural, and renewable resources became of great interest. Here comes the optimistic role of bioprospecting as a promising tool to isolate novel and interesting molecules and microorganisms from the marine environment as alternatives to the existing resources. Bioprospecting of marine metabolites and microorganisms with high biotechnological potentials has gained wide interest due to the variability and richness of the marine environment. Indeed, the existence of extreme conditions that increases the adaptability of marine organisms, especially planktons, allow the presence of interesting biological species that are able to produce novel compounds with multiple health benefits and high economical value. This review aims to provide a comprehensive overview of marine microbial bioprospecting as a growing field of interest. It emphasizes functional bioprospecting that facilitates the discovery of interesting metabolites. Marine bioprospecting was also discussed from a legal aspect for the first time, focusing on the shortcomings of international law. We also summarized the challenges facing bioprospecting in the marine environment including economic feasibility issues.
查看更多>>摘要：Abstract Microalgae are regarded as a rich trove of diverse secondary metabolites that exert remarkable biological activities. In particular, microalgae‐derived bioactive phenolic compounds (MBPCs) are a boon to biopharmaceutical and nutraceutical industries due to their diverse bioactivities, including antimicrobial, anticancer, antiviral, and immunomodulatory activities. The state‐of‐the‐art green technologies for extraction and purification of MBPCs, along with the modern progress in the identification and characterization of MBPCs, have accelerated the discovery of novel active pharmaceutical compounds. However, several factors regulate the production of these bioactive phenolic compounds in microalgae. Furthermore, some microalgae species produce toxic phenolic compounds that negatively impact the aquatic ecosystem, animal, and human life. Therefore, the focus of this review paper is to bring into light the current innovations in bioprospection, extraction, purification, and characterization of MBPCs. This review is also aimed at a better understanding of the physicochemical factors regulating the production of MBPCs at an industrial scale. Finally, the present review covers the recent advances in toxicological evaluation, diverse applications, and future prospects of MBPCs in biopharmaceutical industries.
查看更多>>摘要：Abstract Astaxanthin is a ketocarotenoid, super antioxidant molecule. It has higher antioxidant activity than a range of carotenoids, thus has applications in cosmetics, aquaculture, nutraceuticals, therapeutics, and pharmaceuticals. Naturally, it is derived from Haematococcus pluvialis via a one‐stage process or two‐stage process. Natural astaxanthin significantly reduces oxidative and free‐radical stress as compared to synthetic astaxanthin. The present review summarizes all the aspects of astaxanthin, including its structure, chemistry, bioavailability, and current production technology. Also, this paper gives a detailed mechanism for the potential role of astaxanthin as nutraceuticals for cardiovascular disease prevention, skin protection, antidiabetic and anticancer, cosmetic ingredient, natural food colorant, and feed supplement in poultry and aquaculture. Astaxanthin is one of the high‐valued microalgae products of the future. However, due to some risks involved or not having adequate research in terms of long‐term consumption, it is still yet to be explored by food industries. Although the cost of naturally derived astaxanthin is high, it accounts for only a 1% share in total astaxanthin available in the global market. Therefore, scientists are looking for ways to cut down the cost of natural astaxanthin to be made available to consumers.
Prabhakar MishraN. S. KiranLuiz Fernando Romanholo FerreiraSikandar I. Mulla...
15页
查看更多>>摘要：Abstract Elevated demand and extensive exploitation of cosmetics in day‐to‐day life have hiked up its industrial productions worldwide. Organic and inorganic chemicals like parabens, phthalates, sulfates, and so forth are being applied as constituents towards the formulations, which tend to be the mainspring ecological complication due to their enduring nature and accumulation properties in various sections of the ecosystem. These cosmetic chemicals get accrued into the terrestrial and aquatic systems on account of various anthropogenic activities involving agricultural runoff, industrial discharge, and domestic effluents. Recently, the use of microbes for remediating persistent cosmetic chemicals has gained immense interest. Among different forms of the microbial community being applied as an environmental beneficiary, algae play a vital role in both terrestrial and aquatic ecosystems by their biologically beneficial metabolites and molecules, resulting in the biobenign and efficacious consequences. The use of various bacterial, fungal, and higher plant species has been studied intensely for their bioremediation elements. The bioremediating property of the algal cells through biosorption, bioassimilation, biotransformation, and biodegradation has made it favorable for the removal of persistent and toxic pollutants from the environment. However, the research investigation concerned with the bioremediation potential of the algal kingdom is limited. This review summarizes and provides updated and comprehensive insights into the potential remediation capabilities of algal species against ecologically hazardous pollutants concerning cosmetic chemicals.
查看更多>>摘要：Abstract Biofilm is the syntrophic association of microbial colonies that remain adhered to the biotic and abiotic surfaces with the help of self‐secreted polymeric substances also termed extracellular polymeric substances. Chronic pathogenicity caused by biofilm‐associated pathogenic microorganisms becomes a significant threat in biomedical research.?An extensive search is being made for the antibiofilm agents made from natural sources or their biogenic derivatives due to their effectivity and nontoxicity. Algae being the producer of various biogenic substances are found capable of disintegrating biofilm matrix and eradication of biofilm without exerting any deterrent effect on other biotas in the ecosystem. The current trend in phycological studies includes the exploration of antifouling efficacy among various algal groups. The extracts prepared from about 225 microalgae and cyanobacteria species are found to have antibiofilm activity. Polyunsaturated fatty acids?are the most important component in the algal extract with antibacterial and antibiofilm properties. The antibiofilm activity of the sulfated polysaccharides extracted from a marine alga could be effectively used to remove dental biofilm. Algal extracts are also being used for the preparation of different biogenically synthesized nanoparticles, which are being used as potent antibiofilm agents. Genome editing of algal species by CRISPR/Cas9 may make precise modifications in the algal DNA for improving the algal strains and production of a more effective antibiofouling agent.
Muhammad U. SaeedNazim HussainAreej ShahbazTooba Hameed...
15页
查看更多>>摘要：Abstract Microalgae and cyanobacteria have sparked a lot of interest due to their potential in various industries like biorefineries, biopharmaceuticals, food supplements, nutraceuticals, and other high‐value products. Polysaccharides, vitamins, proteins, enzymes, and steroids are valuable products isolated from microalgae and cyanobacteria and potentially used in health and biomedical applications. Bioactive compounds derived from microalgae and cyanobacteria exhibit various pharmaceutical properties like antibacterial, anticancer, antiviral, antialgal, and antioxidant. From the properties listed above, the research for novel antibiotics has become particularly appropriate. In addition, the possible emergence of resistance against pathogens, as well as the potential decline in antibiotic efficacy, has prompted researchers to look for a new source of antibiotics. Microalgae and cyanobacteria have indicated a great and unexplored potential among these sources. For this reason, microalgae and cyanobacteria have been highlighted for their efficiency in different industrial sectors, as well as for their potential uses in the betterment of human and environmental health. This review gives an overview of bioactive compounds and metabolites with several biological properties isolated from microalgae and cyanobacteria for treating different animal and human diseases.
NSTL
Wiley