查看更多>>摘要：DMAP-catalyzed diastereoselective [3 + 3] spiroannulations of isatin-derived Morita-Baylis-Hillman car-bonates with indoline-2-thiones were achieved. A series of bisindole-annulated thiopyran frameworks were synthesized in good yields with good diastereoselectivities. The strategy developed in this paper offered a novel way for the synthesis of valuable indole-annulated sulfur heterocycle derivatives which might be beneficial in organic synthesis and medicinal chemistry. (c) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：Imidazole hydrochloride, a hydrochloric acid carrier, was used to mediate the decarboxylation of orthopara position amino-substituted aromatic acids and nitrogen-containing heterocyclic acids, which gave excellent yields within a short time. In addition, the method can be well adapted to a gram scale, and the imidazole hydrochloride additives can be appropriately recovered for secondary utilization. (c) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：A pair of novel epimers of benzofuran dimers (1 and 2), together with two known compounds that were considered to be their monomeric precursor, was isolated from the methanol extract of the roots of Eupatorium heterophyllum. The structures of 1 and 2 were elucidated by 1D and 2D NMR, HRFABMS, and DFT calculations of their NMR data, including DP4+ and CP3 analysis, which assisted in determining of their relative configurations. The absolute configurations of the dimers were determined by TDDFT cal-culations of their ECD spectra. (c) 2022 Elsevier Ltd. All rights reserved.
查看更多>>摘要：A base-promoted cascade radical difluoroalkylation/cyclization of acrylamides with ICF2COOEt to synthesize CF2-containing oxindoles and isoquinoline-1,3-diones in moderate to excellent yields was developed under transition metal-free and catalyst-free conditions. This reaction tolerated a variety of functional groups and provided an alternative and mild method for the preparation of difluoroester-substituted fiveand six-membered nitrogen-containing heterocyclic products.
查看更多>>摘要：The cyclotrimerization reactions of enaminones have been efficiently performed in water in the presence of only a small amount of boron trifluoride diethyl etherate. The reactions led to the green synthesis of a variety of 1,3,5-triacylbenzenes without using any metal as catalyst in good to excellent yields at room temperature. (c) 2022 Elsevier Ltd. All rights reserved.
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