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Phytotherapy research
Heyden & Son
Phytotherapy research

Heyden & Son

0951-418X

Phytotherapy research/Journal Phytotherapy researchSCIISTP
正式出版
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    Issue Information

    4页
      原文链接:
    • NSTL

    Phytocompounds and COVID‐19: Two years of knowledge

    Ester Pagano
    5页
      原文链接:
    • NSTL
    • Wiley

    Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

    Fan ZhangYu YanJia ZhangLi Li...
    28页
    查看更多>>摘要：Abstract Iridoid glycosides (IGs) are found in many medicinal and edible plants, such as Gardenia jasminoides, Cistanche tubulosa, Eucommia ulmoides, Rehmanniae Radix, Lonicera japonica, and Cornus officinalis. Loganin, an IG, is one of the main active ingredient of Cornus officinalis Sieb. et Zucc., which approved as a medicinal and edible plant in China. Loganin has been widely concerned due to its extensive pharmacological effects, including anti‐diabetic, antiinflammatory, neuroprotective, and anti‐tumor activities, etc. Studies have shown that these underlying mechanisms include anti‐oxidation, antiinflammation and anti‐apoptosis by regulating a variety of signaling pathways, such as STAT3/NF‐κB, JAK/STAT3, TLR4/NF‐κB, PI3K/Akt, MCP‐1/CCR2, and RAGE/Nox4/p65 NF‐κB signaling pathways. In order to better understand the research status of loganin and promote its application in human health, this paper systematically summarized the phytochemistry, analysis methods, synthesis, pharmacological properties and related mechanisms, and pharmacokinetics based on the research in the past decades.
      原文链接:
    • NSTL
    • Wiley

    Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review

    Nahid NajafiSoghra MehriMahboobeh Ghasemzadeh RahbardarHossein Hosseinzadeh...
    24页
    查看更多>>摘要：Abstract Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha‐lipoic acid (α‐LA) possesses various pharmacological effects, including antidiabetic, antiobesity, hypotensive, and hypolipidemia actions. It exhibits reactive oxygen species scavenger properties against oxidation and age‐related inflammation and refines MetS components. Also, α‐LA activates the 5′ adenosine monophosphate‐activated protein kinase and inhibits the NFκb. It can decrease cholesterol biosynthesis, fatty acid β‐oxidation, and vascular stiffness. α‐LA decreases lipogenesis, cholesterol biosynthesis, low‐density lipoprotein and very low‐density lipoprotein levels, and atherosclerosis. Moreover, α‐LA increases insulin secretion, glucose transport, and insulin sensitivity. These changes occur via PI3K/Akt activation. On the other hand, α‐LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation. In this review, the most relevant articles have been discussed to determine the effects of α‐LA on different components of MetS with a special focus on different molecular mechanisms behind these effects. This review exhibits the potential properties of α‐LA in managing MetS; however, high‐quality studies are needed to confirm the clinical efficacy of α‐LA.
      原文链接:
    • NSTL
    • Wiley

    Dietary polyphenols for management of rheumatoid arthritis: Pharmacotherapy and novel delivery systems

    Siddharth MaitySarika Wairkar
    18页
    查看更多>>摘要：Abstract Rheumatoid arthritis (RA) is a chronic, complex, systemic autoimmune disease causing chronic inflammation, swelling, and pain. It affects pulmonary and ocular physiology, gastrointestinal disturbance, skeletal disorders, and renal malfunctioning. Although conventional and biological drugs available to treat RA are potent and effective, they lead to life‐threatening side effects and patient discomfort. Hence, alternative therapies are explored for their treatment which is safe, effective, and economical. Herbal drugs are widely used as an alternative therapy and some medicinal plants, especially dietary polyphenols proved their efficacy in treating RA. Polyphenols are secondary metabolites of plants possessing several pharmacological actions. They exert anti‐inflammatory, immunomodulatory and anti‐rheumatoid activity by modulating tumor necrosis factor, mitogen‐activated protein kinase, nuclear factor kappa‐light‐chain‐enhancer of activated B cells, and c‐Jun N‐terminal kinases. Thus, polyphenols could be a promising option for the management of RA. Unfortunately, polyphenols suffer from poor bioavailability due to their physicochemical properties and incorporation into novel delivery systems such as liposomes, nanoparticles, nanoemulsions, micelles improved their oral bioavailability. This review article summarizes dietary polyphenols, their pharmacological actions and novel delivery systems for the treatment of RA. Nevertheless, the commercial translation of polyphenols could be only possible after establishing their safety profile and successful clinical trials.
      原文链接:
    • NSTL
    • Wiley

    A critical review on clinical evidence of the efficacy of lavender in sleep disorders

    Jing LuoWubian Jiang
    10页
    查看更多>>摘要：Abstract Sleep disorders are one of the most prevalent psychiatric diseases. Insomnia is the most common sleep disorder amongst the general population. It is also one of the?most frequent complaints in primary healthcare centers. Lavender is called “the broom of the brain” in different oriental traditional medicines. It is one of the most used plants for patients with sleep disorders. This study reviews what is currently known about the use of lavender for sleep disorders in patients with different diseases, from cancers and end‐stage renal disease to neurological‐psychiatric diseases (e.g., depression, dementia, and autism), respiratory, cardiac, and metabolic diseases. Additionally, its most used administration route is the inhalation of its essential oil (i.e., aromatherapy) alone or in combination by massage. Some limitations of the reviewed literature were discussed briefly. Overall, this critical review provides promising evidence of the lavender efficacy for sleep disorders in a wide variety of populations and diseases. However, further clinical studies with robust design and longer durations of intervention are necessary for more evidence‐based judgment on its effect on sleep problems and to investigate its mechanism of action.
      原文链接:
    • NSTL
    • Wiley

    The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects

    Elyas Nattagh‐EshtivaniAlireza GheflatiHanieh BarghchiPegah Rahbarinejad...
    23页
    查看更多>>摘要：Abstract The prevalence of chronic diseases has increased significantly with the rising trend of sedentary lifestyles, reduced physical activity, and dietary modifications in recent decades. Inflammation and oxidative stress play a key role in the pathophysiology of several chronic diseases, such as type II diabetes, cardiovascular diseases, and hepatic conditions. Therefore, reducing inflammation and oxidative stress may be beneficial in the prevention and treatment of various chronic disorders. Since chronic diseases are not completely curable, various methods have been proposed for their control. Complementary therapies and the use of natural antioxidant and antiinflammatory compounds are among these novel approaches. Pycnogenol (PYC) is a natural compound that could control inflammation and oxidative stress. Furthermore, some previous studies have shown that PYC could effectively reduce inflammation through signaling the downstream of insulin receptors, inhibiting the phosphorylation of the serine residues of insulin receptor substrate‐1, reducing pro‐inflammatory cytokines and oxidative stress indices through the stimulation of antioxidant pathways, increasing free radical scavenging activities, preventing lipid peroxidation, and protecting the erythrocytes in glucose‐6‐phosphate dehydrogenase‐deficient individuals, although these effects have not been fully proved. The present study aimed to comprehensively review the evidence concerning the positive physiological and pharmacological properties of PYC, with an emphasis on the therapeutic potential of this natural component for enhancing human health.
      原文链接:
    • NSTL
    • Wiley

    A review: Pharmacology and pharmacokinetics of Schisandrin A

    Lihong GongKe FuHonglin ZhouCheng Wang...
    19页
    查看更多>>摘要：Abstract Schisandrin A (SA) is a bioactive lignan isolated from the traditional Chinese medicine Fructus schisandrae chinensis. In recent years, it has attracted extensive attention because of its multiple pharmacological activities. This review is the first to provide an overview of SA‐related pharmacological effects and pharmacokinetic characteristics. The results showed that SA had many pharmacological effects, such as antiinflammation, anticancer, hepatoprotection, antioxidation, neuroprotection, antidiabetes mellitus, and musculoskeletal protection. Among them, NF‐κB, Nrf2, MAPK, NLRP3, PI3K/AKT, Wnt, miRNA, P‐gp, CYP450, PXR, and other signal transduction pathways are involved. Pharmacokinetic studies showed that SA had good pharmacokinetic characteristics, but these were affected by other factors, such as drugs or hepatic fibrosis. Thus, SA has a variety of pharmacological effects and good pharmacokinetic characteristics, which is worthy of further research and development in the future.
      原文链接:
    • NSTL
    • Wiley

    A critical evaluation of risk to reward ratio of quercetin supplementation for COVID‐19 and associated comorbid conditions

    Anil PawarMaria RussoIsha RaniKalyan Goswami...
    22页
    查看更多>>摘要：Abstract The interim results of the large, multinational trials on coronavirus disease 2019 (COVID‐19) using a combination of antiviral drugs appear to have little to no effect on the 28‐day mortality or the in‐hospital course. Therefore, there is a still vivid interest in finding alternate re‐purposed drugs and nutrition supplements, which can halt or slow the disease severity. We review here the multiple preclinical studies, partially supported by clinical evidence showing the quercetin's possible therapeutic/prophylaxis efficacy against severe acute respiratory syndrome coronavirus (SARS‐CoV) as well as comorbidities like chronic obstructive pulmonary disease (COPD), diabetes mellitus, obesity, coagulopathy, and hypertension. Currently, 14 interventional clinical trials are underway assessing the efficacy of quercetin along with other antiviral drugs/nutritional supplements as prophylaxis/treatment option against COVID‐19. The present review is tempting to suggest that, based on circumstantial scientific evidence and preliminary clinical data, the flavonoid quercetin can ameliorate COVID‐19 infection and symptoms acting in concert on two parallel and independent paths: inhibiting key factors responsible for SARS‐CoV‐2 infections and mitigating the clinical manifestations of the disease in patients with comorbid conditions. Despite the broad therapeutic properties of quercetin, further high power randomized clinical trials are needed to firmly establish its clinical efficacy against COVID‐19.
      原文链接:
    • NSTL
    • Wiley

    Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review

    Mariana Hipólito‐ReisAna Catarina NetoDelminda Neves
    18页
    查看更多>>摘要：Abstract Endometriosis, a gynecological disease that affects reproductive age women is difficultly controlled in the long term by currently available treatments, prompting patients to adopt self‐controlled interventions including dietary changes. The aim of this review is to provide evidence of how curcumin, quercetin, and resveratrol can act as natural interventions to control endometriosis. The review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines. A comprehensive search was carried out in PubMed, Scopus, and Web of Science to gather together all the articles that study the specific actions of curcumin, resveratrol, or quercetin in endometriosis pathophysiology. All types of study designs including experimental data were considered. Thirty articles, including a clinical trial, were included. For the assessment of the quality of the selected studies that globally have “good quality”, the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and the SYRCLE ROB tool criteria were used. By acting on mechanisms of inflammation, oxidative stress, cell proliferation, invasion and adhesion, apoptosis, angiogenesis and glucose and lipid metabolism, curcumin, quercetin, and resveratrol showed to have beneficial effects, evidencing their potential application in the endometriosis treatment. However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.
      原文链接:
    • NSTL
    • Wiley