首页|A review: Pharmacology and pharmacokinetics of Schisandrin A
A review: Pharmacology and pharmacokinetics of Schisandrin A
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NSTL
Wiley
Abstract Schisandrin A (SA) is a bioactive lignan isolated from the traditional Chinese medicine Fructus schisandrae chinensis. In recent years, it has attracted extensive attention because of its multiple pharmacological activities. This review is the first to provide an overview of SA‐related pharmacological effects and pharmacokinetic characteristics. The results showed that SA had many pharmacological effects, such as antiinflammation, anticancer, hepatoprotection, antioxidation, neuroprotection, antidiabetes mellitus, and musculoskeletal protection. Among them, NF‐κB, Nrf2, MAPK, NLRP3, PI3K/AKT, Wnt, miRNA, P‐gp, CYP450, PXR, and other signal transduction pathways are involved. Pharmacokinetic studies showed that SA had good pharmacokinetic characteristics, but these were affected by other factors, such as drugs or hepatic fibrosis. Thus, SA has a variety of pharmacological effects and good pharmacokinetic characteristics, which is worthy of further research and development in the future.
anticancerantiinflammatoryhepatoprotectivepharmacokineticspharmacological activitiesSchisandrin A
Lihong Gong、Ke Fu、Honglin Zhou、Cheng Wang、Yafang Zhang、Yunxia Li、Cheng Ma
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Chengdu University of Traditional Chinese Medicine
NSTL
Wiley
