Fongaro, L.Knott, A.Nicholl, A.Mayer, K....
9页查看更多>>摘要：Nuclear Forensics is a rapidly evolving field with a steadily increasing number of publications. Research in developing or consolidating signatures and methods in various analytical areas, such as elemental and isotopic parameters, age dating and morphology have resulted in significant progress. Moreover, the development of new reference materials for uranium ore concentrate, the application of micro-analytical techniques and the increasing use of data evaluation techniques such as machine learning or deep learning further add to the nuclear forensic toolbox. The examination of samples from real incidents demonstrate the usefulness and the investigative value of nuclear forensic techniques. (C) 2021 The Author(s). Published by Elsevier B.V.
原文链接:
NSTL
Elsevier
Wang, LinlinZhang, Jian-RongWu, XiaogeZhu, Jun-Jie...
9页查看更多>>摘要：Tumors are the leading killers of human health, however, diagnosis on tumors are neither timely nor accurate due to the high detection cost and high technical requirements. For cancer diagnosis and treatment, self-powered biosensors based on enzymatic biofuel cells have the advantages of simple structure, easy miniaturization, instantaneous response to analytes, and high economic applicability. It is of great significance for the development of portable and personalized biosensors. Over the past twenty years, a number of prominent self-powered biosensors have been created to diagnose tumor via analyzing the corresponding biomarkers with low cost. What's more, some intelligent self-powered biosensors with integrated diagnostic and therapeutic functions have also been reported. In this review, the focus of this work is on the development of self-powered biosensors in tumor diagnosis and intelligent regulation from the aspects of design and working principles. Furthermore, the challenge for the future work is also analyzed. (C) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Ozcelikay, G.Kaya, S., IOzkan, E.Cetinkaya, A....
12页查看更多>>摘要：In recent years, metabolomics, identification and profiling of metabolites, have gained broad interest compared to other omics technologies and are progressively being utilized for biomarker discoveries. Therefore, the application of metabolomics in different fields are increasing day by day because of its high throughput results. However, the application of metabolomics requires state-of-the-art analytical approaches for the analysis. The complexity and limited availability of these instruments are restricting parameters for applying metabolomics studies in routine analysis. This problem may be overcome with molecularly imprinted polymer (MIP)-based electro sensors since they have high selectivity, sensitivity, easy applicability, portability, and low cost. This is the final step before developing end point-of-care tests (POCT), which patients can easily apply. MIP sensors will have more applications in the targeted metabolomics analysis to develop POCT systems. This review analyzes various metabolites using MIP-based electrochemical methods for their potential usage as POCT and biomarker research based on targeted metabolomics analysis requirements. The future applications for the sensitive assay of metabolites in medicine and clinical trials are also discussed. (C) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Goryacheva, Olga A.Ponomaryova, Tatiana D.Drozd, Daniil D.Kokorina, Alina A....
12页查看更多>>摘要：In the context of the high risk of heart failure (HF), rapid assessment of biomarker levels in patients appears to be a quick and accurate approach to diagnosis and timely treatment. Brain natriuretic peptide (BNP) and N-terminal fragment of the prohormone BNP (NT-proBNP) are widely used as biomarkers of HF, primarily ventricular dysfunction, for diagnosis, treatment and risk assessment. A major strength of BNP and NT-proBNP is their high negative predictive value: they are useful in exclusion of HF as a cause of non-specific symptoms. In this review we consider the features of the presence of BNP and NT-proBNP in a cocktail of natriuretic peptides in the bloodstream, as well as challenges, skeleton concepts and characteristic methods for BNP and NT-proBNP detection using optical labels. We consider the most important points for analysis and diagnostics, approaches for improving diagnostic value, as well as sensitivity and reproducibility. (C) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Su, DiWang, XinZhang, WenLi, Ping...
13页查看更多>>摘要：Lipid peroxidation is accompanied with producing series of bioactive molecules, including lipid radicals, lipid peroxyl radicals, lipid hydroperoxide and some reactive carbonyl species. These highly bioactive molecules play vital roles in cell biology. For clarifying the biological mechanisms and physiopathological functions of these molecules, exploitation of accurate detection methods is essential. As fluorescence imaging technique own extraordinary capacity for tracking bio-species in living systems, developing fluorescence imaging tools for these bioactive molecules has become one convictive direction. Numbers of relevant papers have emerged in decades while lacking systematically review so far. To afford some serviceable guidance for future research in lipid peroxidation, we generalize the construction strategies and biological imaging applications of the fluorescence tools for the related bioactive molecules according to the produced order, which will spark new ideas and future applications in lipid peroxidation. (C) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
Lee, Tung-ChunChio, Weng-I KatherineXie, HuiminZhang, Yuewen...
9页查看更多>>摘要：Hierarchical self-assembly of nanoparticles (NPs) mediated by macrocyclic molecules, cucurbiturils (CBs), provides a facile method to fabricate surface-enhanced Raman spectroscopy (SERS) sensors for potential applications in biosensing and environmental monitoring. In contrast to conventional techniques for wastewater-based epidemiology (WBE), CB-NP SERS sensors offer great opportunities for on-site quantification of trace chemical and biological markers due to its high sensitivity, selectivity, reproducibility, multiplexing capability and tolerance against contamination. The working principles of the CB-Au NP nanocomposites including fabrication, sensing mechanisms and structure-property relationships are explained while the design guidelines and selected examples of CB-Au NP SERS sensors are discussed. The review concludes by highlighting recent advances in this area and exploring opportunities in the context of WBE.(c) 2021 Elsevier B.V. All rights reserved.
原文链接:- NSTL
- Elsevier
