首页|Heart failure biomarkers BNP and NT-proBNP detection using optical labels

Heart failure biomarkers BNP and NT-proBNP detection using optical labels

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  • NSTL
  • Elsevier
In the context of the high risk of heart failure (HF), rapid assessment of biomarker levels in patients appears to be a quick and accurate approach to diagnosis and timely treatment. Brain natriuretic peptide (BNP) and N-terminal fragment of the prohormone BNP (NT-proBNP) are widely used as biomarkers of HF, primarily ventricular dysfunction, for diagnosis, treatment and risk assessment. A major strength of BNP and NT-proBNP is their high negative predictive value: they are useful in exclusion of HF as a cause of non-specific symptoms. In this review we consider the features of the presence of BNP and NT-proBNP in a cocktail of natriuretic peptides in the bloodstream, as well as challenges, skeleton concepts and characteristic methods for BNP and NT-proBNP detection using optical labels. We consider the most important points for analysis and diagnostics, approaches for improving diagnostic value, as well as sensitivity and reproducibility. (C) 2021 Elsevier B.V. All rights reserved.

Brain natriuretic peptide BNPN-terminal fragment of the prohormoneBNP NT-proBNPHeart failure biomarker detectionOptical labelsImmunoassayBRAIN NATRIURETIC PEPTIDEHIGHLY SENSITIVE DETECTIONEUROPEAN-SOCIETYTASK-FORCECROSS-REACTIVITYESC GUIDELINESIMMUNOASSAYASSOCIATIONDIAGNOSISASSAYS

Goryacheva, Olga A.、Ponomaryova, Tatiana D.、Drozd, Daniil D.、Kokorina, Alina A.、Rusanova, Tatiana Yu、Mishra, Pradyumna K.、Goryacheva, Irina Yu

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Saratov NG Chernyshevskii State Univ

ICMR Natl Inst Res Environm Hlth

2022

10.1016/j.trac.2021.116477

TrAC

TrAC

ISSN：0165-9936
年,卷(期)：2022.146
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